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ceh-18

Gene
ceh-18
Protein
Homeobox protein ceh-18
Organism
Caenorhabditis elegans
Length
542 amino acids
Function
Directs gonadal sheath cell differentiation and function (PubMed:9405097). Also directs gonad migration and plays a role in specifying the differentiated phenotypes of epidermal cells during postembryonic development (PubMed:7958868). Plays a role in oogenesis, regulating a sheath cell signal that causes oocytes to maintain diakinesis arrest during meiosis (PubMed:7958868). Negatively regulates oocyte maturation, ovulation and MAPK activation in oocytes when sperm are not available for fertilization (PubMed:12533508). May be recruited by akir-1 to the promoter regions of antimicrobial peptide genes to control gene expression in response to fungal infection (PubMed:30036395).
Similarity
Belongs to the POU transcription factor family.
Mass
59.48 kDa
Sequence
MNTLENTFQFLAEVFEANGGCLVTERVSPSLSGASKRKSRPVKRIITEDEVIPEEEVVEEEEEEKVEQPSEEVTCPAMQVDATDAILASLRQIANNDLSEHCIREDEGNTSAEVFSNGNGEDMEQAGLAGTDLLRRVADMLQGNHNGSLNSHFLQQQFAAFKETVDPTPVSTNGNGLLTPITTQLSPLFTSTDAFNSPEKLLQAIMTPSLGFLGANGLGASNSGLLSSPLIAPSPTLLQSLMNTPTQPTASLTPKKAENRPPVVSQTLKASKRRLFDDTSRIEAASMSGDDRIDMNELEAFAQTFKKQRIKFGFTQGDVGVALGKRYGTDFSQTTISRFEALNLSFKNMCKLRPLLKEWLADVEMAIEGGATVTDLIDKKTIHNGNHHTIHHVDIHETSISNSISSVTASSLLSREQHVKRRRKRTNLDMNQRNALDTFFALNPRPDHDKMTDIANSLELDRDVVRVWFCNRRQKMRRVDEPIEGEMVTPSVSPVFPHFSSMSALEQIQEAARLASCQASNDDSDGTSGSPDAPSNDGCSDL