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ced-1

Gene
ced-1
Protein
Cell death abnormality protein 1
Organism
Caenorhabditis briggsae
Length
1134 amino acids
Function
Involved in programmed cell death/apoptosis. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (By similarity).
Mass
121.087 kDa
Sequence
MRLLLLVGVLLAATWQVGYTRAPTFPDKSKSAADAINEPKGEHVCTVKTIVDDYELRKVIHQVVYNDTEQCLNPLTGFQCVVEKRGQKASYQRQLVQKEKYIKQCCEGYYQTKDNQCQPDCNPPCKKGKCVEPGKCECDPGFGGKICSSSCSIGTWGLGCSKKCDCENGANCDPELGDCICPSGFQGKRCEEECPIDKWGPNCVKSCPCQNGGKCNHEGKCVCTDGWGGEYCLNKCEEGKFGADCKFECTCQNGATCDNTNGKCLCKSGFHGALCEKPCSEGFFGAGCTQKCQCLNNQDCDSETGECKCIGWTGKQCDIGCARGRFGLQCKQKCTCPGLEFQDSNASCDAKTGECQCESGYKGANCDERKCSADTYGADCSKQCSCVMSNTVMCAPNTGFCRCKPGFYGDNCELACSKDSYGPNCEKQAMCDWTHASEADPANGKCVCKSGRSGANCSQPCPIDFYGPNCALQCECNGRGIGCHGFDGKCNCAPGYTGHRCEHHCPALTFGANCEKRCQCPAGVGCNPITGECECPAGRQGLKCDISCPEGSYGPECKLHCKCVNGKCDPETGECSCEPGFGGADCSTSCPKGKYGDACELSCDCSDSYCSRQTGKCICPLGKKGTLCDQPCEANTYGPQCQLTTTPSQCASTDPRNGVCLTCPPGSSGHQCEQNCPQGTYGTDCASKCACADGGHGCDPTTGECICEPGYHGATCSEKCPDGKFGYACAQNCPKCAAGSSCDHISGQCVCPAGLEGATCTRPCGVGFWGNGCRQVCRCTSEFKQCNAQTGECSCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATASCNRVTGVCICHPGFTGEFCHALCPESTFGLRCSKECPKDGCGDGYECDAAIGCCHVDQMSCGKAKQEFEALNGGRAKSSGATWLLILFIIGLCGVLGLAALFYRNKYQKEKDPDMPTVSFHKSPNAEDNREFQNPLYNRQSVFPDSGAFSGSSEGGVGAAPDGLLTLEEEDLEDKKIHGGGASRNMRNHDYASLDEVAGGEGGPATSSSSGVQNRRGQNSGDVRRPLLNSEDVDDDDEDEDFEEIPHENRNSTQKLSLERNSKFSEKNFKKKFLSENPYAHIPSPDPNIQNSTNSRRAQENLYT

Gene
ced-1
Protein
Cell death abnormality protein 1
Organism
Caenorhabditis elegans
Length
1111 amino acids
Function
Involved in programmed cell death, also called apoptosis, in both somatic and germ cells (PubMed:11163239, PubMed:6857247, PubMed:1936965, PubMed:15744306, PubMed:16740477, PubMed:18351800, PubMed:26598553, PubMed:27650246). Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse (PubMed:15744306). Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation (PubMed:16740477, PubMed:18351800). Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (PubMed:18606143).
Mass
118.804 kDa
Sequence
MRLILLVLLATWQVVVDTRAPTFPDKLTQQLQQQGTTEPQGDHVCTVKTIVDDYELKKVIHTVVYNDTEQCLNPLTGFQCTVEKRGQKASYQRQLVKKEKYVKQCCDGYYQTKDHFCLPDCNPPCKKGKCIEPGKCECDPGYGGKYCASSCSVGTWGLGCSKSCDCENGANCDPELGTCICTSGFQGERCEKPCPDNKWGPNCVKSCPCQNGGKCNKEGKCVCSDGWGGEFCLNKCEEGKFGAECKFECNCQNGATCDNTNGKCICKSGYHGALCENECSVGFFGSGCTQKCDCLNNQNCDSSSGECKCIGWTGKHCDIGCSRGRFGLQCKQNCTCPGLEFSDSNASCDAKTGQCQCESGYKGPKCDERKCDAEQYGADCSKTCTCVRENTLMCAPNTGFCRCKPGFYGDNCELACSKDSYGPNCEKQAMCDWNHASECNPETGSCVCKPGRTGKNCSEPCPLDFYGPNCAHQCQCNQRGVGCDGADGKCQCDRGWTGHRCEHHCPADTFGANCEKRCKCPKGIGCDPITGECTCPAGLQGANCDIGCPEGSYGPGCKLHCKCVNGKCDKETGECTCQPGFFGSDCSTTCSKGKYGESCELSCPCSDASCSKQTGKCLCPLGTKGVSCDQKCDPNTFGFLCQETVTPSPCASTDPKNGVCLSCPPGSSGIHCEHNCPAGSYGDGCQQVCSCADGHGCDPTTGECICEPGYHGKTCSEKCPDGKYGYGCALDCPKCASGSTCDHINGLCICPAGLEGALCTRPCSAGFWGNGCRQVCRCTSEYKQCNAQTGECSCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATSSCNRVSGACHCHPGFTGEFCHALCPESTFGLKCSKECPKDGCGDGYECDAAIGCCHVDQMSCGKAKQEFEALNGAGRSTGLTWFFVLLIVALCGGLGLIALFYRNKYQKEKDPDMPTVSFHKAPNNDEGREFQNPLYSRQSVFPDSDAFSSENNGNHQGGPPNGLLTLEEEELENKKIHGRSAAGRGNNDYASLDEVAGEGSSSSASASASRRGLNSSEQSRRPLLEEHDEEEFDEPHENSISPAHAVTTSNHNENPYADISSPDPVTQNSANKKRAQDNLYT