Protein
Coiled-coil domain-containing protein 78
Function
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for cep152 localization to the deuterosome.
Similarity
Belongs to the CCDC78 family.
Sequence
MDSTEDRETPLKDQIRRLTNENVQLQDRNERLYAKLGELQDKMGKLAGSKTDLSSKLVLSEEEKLKISKELIELQIETNKIREHYEAETFELKNTILTLENRLMSLELQKEKLAGEHESVKERLQAVDANRKELADEYIVLKSNYLALSKEHEKEVAKNDELSMELLNLASRRGQDETYSQSRALVNEATAELDRVKAMVNRLSARNIKPEDLVATEYERQKLERNLLGNQDHIREEIENMKKIHETQQQRLEERIIAMGKELQEAKRAIRNTQHKMAEQSAVLLTSQSQLQETEAQNSHLQLQLKELNEEYRSRLNRYIQDLADYVDGTARSKGDGTRMKHFVDNMLSDIKASHRSREEQLAGAARQYKKRMQNLIKKHQSLLIAYRMQREQLLASGNQDVEPGPPEHHFTITDPELQSQVGLELNRLREDKARLETQIHDLKEKKRLSDAGTSNQHVEHGGKLQEESWAEIRKQLREFTHNTQEELERERSQLLSRALVAEEQVAELQDYVDKHLARYKQEILRLRKLLGNEEQRAVSADAPQSLLIRALRRNSHEM