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ccdc78

Gene
ccdc78
Protein
Coiled-coil domain-containing protein 78
Organism
Xenopus laevis
Length
559 amino acids
Function
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for cep152 localization to the deuterosome.
Similarity
Belongs to the CCDC78 family.
Mass
65.184 kDa
Sequence
MDSTEDRETPLKDQIRRLTNENVQLQDRNERLYAKLGELQDKMGKLAGSKTDLSSKLVLSEEEKLKISKELIELQIETNKIREHYEAETFELKNTILTLENRLMSLELQKEKLAGEHESVKERLQAVDANRKELADEYIVLKSNYLALSKEHEKEVAKNDELSMELLNLASRRGQDETYSQSRALVNEATAELDRVKAMVNRLSARNIKPEDLVATEYERQKLERNLLGNQDHIREEIENMKKIHETQQQRLEERIIAMGKELQEAKRAIRNTQHKMAEQSAVLLTSQSQLQETEAQNSHLQLQLKELNEEYRSRLNRYIQDLADYVDGTARSKGDGTRMKHFVDNMLSDIKASHRSREEQLAGAARQYKKRMQNLIKKHQSLLIAYRMQREQLLASGNQDVEPGPPEHHFTITDPELQSQVGLELNRLREDKARLETQIHDLKEKKRLSDAGTSNQHVEHGGKLQEESWAEIRKQLREFTHNTQEELERERSQLLSRALVAEEQVAELQDYVDKHLARYKQEILRLRKLLGNEEQRAVSADAPQSLLIRALRRNSHEM

Gene
CCDC78
Protein
Coiled-coil domain-containing protein 78
Organism
Homo sapiens
Length
438 amino acids
Function
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome.
Similarity
Belongs to the CCDC78 family.
Mass
48.521 kDa
Sequence
MEHAATTGPRPGPPSRRVENVVLRAKDWLPGAPGGTAVWATSLEAEVPPDLALNKEQQLQISKELVDIQITTHHLHEQHEAEIFQLKSEILRLESRVLELELRGDGTSQGCAVPVESDPRHPRAAAQELRHKAQVPGHSDDHRFQVQPKNTMNPENEQHRLGSGLQGEVKWALEHQEARQQALVTRVATLGRQLQGAREEARAAGQRLATQAVVLCSCQGQLRQAEAENARLQLQLKKLKDEYVLRLQHCAWQAVEHADGAGQAPATTALRTFLEATLEDIRAAHRSREQQLARAARSYHKRLVDLSRRHEELLVAYRAPGNPQAIFDIASLDLEPLPVPLVTDFSHREDQHGGPGALLSSPKKRPGGASQGGTSEPQGLDAASWAQIHQKLRDFSRSTQSWNGSGHSCWSGPRWLKSNFLSYRSTWTSTWAGTSTKS

Gene
Ccdc78
Protein
Coiled-coil domain-containing protein 78
Organism
Mus musculus
Length
437 amino acids
Function
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome (By similarity).
Similarity
Belongs to the CCDC78 family.
Mass
49.472 kDa
Sequence
MDQRPELLSSMEYVASPDPKPGVPLRVAENVAPGAEDWLPSASGHLAWATSLETEHQTHLELSEEQRLQISKELVDLQIATHHLREQHEAEVFELRREILRLESRVLELELHGNGACQGHKVQPMANLGQHQVPPLEPPGGQQKLQEELKWLLEHHRARQQALETQVGVLSQQLQGAREEARTTGQQLASQAMVLASCKGQLRQAEAENTQLQLQLKKMNEEYAVRLQHYARETVENASSTNQAALQAFLESTLQDIRAAHRTREQQLAQAARTYRKRLADLNQRQELLLTTCRATFATAINLEPLPMHWATELSHPRENEYGRHRTLLLYPEKGSGETSKENKSQPLALDTASWAQIQQRLQDFSQDTQAELERERAQLMVRATMAEQQLSELQEYVDQHLGRYKQEILKLRKLVNIGDPQGVEAVSSPGSGGARL