Protein
Basal body-orientation factor 1
Function
Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
Similarity
Belongs to the BBOF1 family.
Sequence
MPKLKVKAGKGKKGKRKKAGKNEHRLDKESEVERARSNAALWEARLKVTEFSRVEYRDAARSLAQNNEDLTKQQYKLEKDMVEVIGFLKKQDLEKDELIEKLQQNLIAQKKSAQDEREKLVELYSKQIAHLEENYSQKTNEMQIIQSEFKLMREFRRQKVELEKELDEVKESLWRANQDHKETLARMERRFFEEKQRLEKEAEKKIMMLAEKAHSEAIIQLDEARKSVFKENVRLKEAFSYHLKEMKDIKKSKKMQEDAKLHLLQEKETNDLLVQEKVSQVSQKKVQIQELQQNVKALECALERMTMEMEKDAQGKEHQALLQEQAGNVELQKLQKVLHMKEREMNRIKKLARNILEERTEVESFFLEALWQVKQEIATSRNYYRQVAQSAYTSKMIQASLGKDQYPKIRTFHNKEHSTNDVSHDLSEAEKWTHIQAGKVDIGDLTWEQKEKVLRLLFAKMNGFQSRKSPGLKPSPPADVSSIKEKEINTSNLEEKPEESSSTFITQSIPELPAPSLVLPHIQTGRCQVTG