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cbiX

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
336 amino acids
Function
Chelates cobalt to the cobalamin precursor as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXL subfamily.
Mass
38.34 kDa
Sequence
MTLTSVPAPVSLFPELELPPLPYHRPLLMIGHGTRDEDGRQTFLDFVAQYQALDHSRPVIPCFLELTEPNIQAGVQQCVDQGFEEISALPILLFAARHNKFDVTNELDRSRQAHPQINFFYGRHFGITPAILDLWKARLNQLDSPEANPQGIDRQDTVLLFVGRGSSDPDANGDVYKMARMLWEGSGYQTVETCFIGISHPRLEEGFRRARLYQPKRIIVLPYFLFMGALVKKIFTITEEQRATFPEIEIQSLSEMGIQPELLALVREREIETQLGQVAMNCEACKFRLAFKNQGHGHDHGHGHHHHGHDHGHSHGEWVDTYIEPTAYHEKIWQAP

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Bacillus megaterium
Length
306 amino acids
Function
Chelates cobalt to the cobalamin precursor as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXL subfamily.
Mass
34.882 kDa
Sequence
MGGHYMKSVLFVGHGSRDPEGNDREFISTMKHDWDASILVETCFLEFERPNVSQGIDTCVAKGAQDVVVIPIMLLPAGHSKIHIPAAIDEAKEKYPHVNFVYGRPIGVHEEALEILKTRLQESGENLETPAEDTAVIVLGRGGSDPDANSDLYKITRLLWEKTNYKIVETSFMGVTAPLIDEGVERCLKLGAKKVVILPYFLFTGVLIKRLEEMVKQYKMQHENIEFKLAGYFGFHPKLQTILKERAEEGLEGEVKMNCDTCQYRLGIMEHIDHHHHHDHDHDHDHGHHHHDHHHDHHEDKVGELK

Gene
cbiX
Protein
Probable sirohydrochlorin cobaltochelatase
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
Length
292 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
31.985 kDa
Sequence
MQALVIVGHGSHLNPGSSEPAYTHADTIRESGAFDEVREAFWKEEPSFRNVLRTLESDEVYVVPLFISEGYFTEQVIPRELRLDDFDPDDWDSDGTDADHVTLEADDVEKTIHYCGPVGTHDSMSEVIVQRASSVTGREEFGDDFGLAVVGHGTERNENSAKAIYYHADQIREMGVFGEVQAVFMDEDPEVDDVTDFFDTDDIVVVPLFVSDGFHTQEDIPEDMGLTDDYRTGYDIPTAVDGHDIWYSGAVGTEPLAADVVLERAADAGAPVGDAVDAVREQTRGANAAAGD

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Methanococcus maripaludis (strain S2 / LL)
Length
144 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
16.107 kDa
Sequence
MEALVLVGHGSRLPHSKNVVMEVAEKIKARNIYDIVEVGMMEFNEPTIPQTIKKVIDAGAKKVIVTPVFLAPGNHTERDIPKILGIYEGDDEGGHHHHHDHEHHHHHHDTTAVEIPEGVELVYRKPMGADDRIIDIVLDRANGL

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Length
143 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
16.09 kDa
Sequence
MEALVLLGHGSRLPYSKEIVGKVAEKIKEKNIYDIVEIGMMEFNEPTIPQTINKVIAEGAKKIIIVPVFLAHGNHTKRDIPQILGLIECEEHHHEGEGGHHHHHHHHHGEKIEVPEGVEIIYRDPMGADDRVVDIVLDRAKGN

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
143 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
16.519 kDa
Sequence
MEALVLVGHGSRLPYSKELLVKLAEKVKERNLFPIVEIGLMEFSEPTIPQAVKKAIEQGAKRIIVVPVFLAHGIHTTRDIPRLLGLIEDNHEHHHEHSHHHHHHHHHEHEKLEIPEDVEIIYREPIGADDRIVDIIIDRAFGR

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
143 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
16.083 kDa
Sequence
MVAVVLVGHGSRLPYSRQVVEKIAEYVEEMGDFETVEVGFMELCEPTVQEAVKKAAESGVDKIVVVPVFLAHGVHTKRDIPKMLGLEPEWDDDEDDHDHHHHHHRDYTPVDVDAEIVYAEPLGADPRIAEIVIDRIKEALGEE

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
143 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (PubMed:12686546). Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (Potential). Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (Potential).
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
15.826 kDa
Sequence
MDSNSNQKPKIGVLLVGHGSRLPYGEEVINGIADIYRQEADHPVAVGFMNMSRPSIPEAINELAAMGVEKIIVTPVFLAHGVHTKHDIPHILGLDNGAEGHHHHEHEHEHEEFEFDGEIVYTEPLGADPRIAEIIRDRVKSAI

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
132 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
15.109 kDa
Sequence
MRRGLVIVGHGSQLNHYREVMELHRKRIEESGAFDEVKIAFAARKRRPMPDEAIREMNCDIIYVVPLFISYGLHVTEDLPDLLGFPRGRGIKEGEFEGKKVVICEPIGEDYFVTYAILNSVFRIGRDGKGEE

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Length
131 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
14.178 kDa
Sequence
MSEKIGILAIGHGSRLPYNKEVVSEIAATIAKKHPDYVIKAGFMENTLPTVMEALADFDGTGVTKIIAVPVFLASGVHITEDIPEILKLDPETNEGKITVDGNEIPVTFGKPLGHHELLADLVFERAMEVM

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
130 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (Potential). Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (PubMed:27846569). Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (PubMed:27846569).
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
13.746 kDa
Sequence
MTEKLGILAIGHGSKLPYNKEVVSQIADYIAQKHSDVVVRAGFMENSEPTLEEAIAGFAGTGVTKIAAVPVFLASGVHITKDIPGILSLDEKGCGILNIDGKDVPLCYAKPLGADELIADLVFKRVQEAL

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Length
130 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (PubMed:12686546). Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (PubMed:28225763). Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (PubMed:28225763).
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
13.85 kDa
Sequence
MTEKLGILAIGHGSKLPYNKEVVTQIADYIARKHSDVVVRAGFMENSEPTLGEAIEGFSGTGVTKIAAVPVFLASGVHITKDIPRILSLDENGCGTLEIDGKTVPLCYANPLGADELIADLVFKRVQEAL

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
130 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
13.98 kDa
Sequence
MTEKLGILAIGHGSKLPYNKEVVTQIANYIAQKHSDVVVRAGFMENSEPTLEEAIEGFSGTGVTKISAVPVFLASGVHITKDIPEILSLDKEGCGILEIDGKEVPLCYAKPLGADELIAELVFKRVQESL

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
128 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
14.606 kDa
Sequence
MLGVLLVLHGSKIPEWKDVGIKYAEYLSKYFSLVEFGFLEFNKPTLSEALSNLLAKGADKIVVVPLLFATGTHFRRDIPRLLGIDNDEKKIRYMGREIEITIADPLGFDEKIGEVLVKRVNETYNKNY

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Sulfolobus islandicus (strain M.16.27)
Length
128 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
14.531 kDa
Sequence
MLGVLLVLHGSKIPEWKDVGIKYAEYLSRYFNLVEFGFLEFNKPTLSEALSNLLAKGANKIVVVPLLFATGTHFKRDIPRLLGIDGDEKKIQYMGKEIEIIIADPLGFDEKIGEVLVKRVNETYNKNY

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Length
128 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
14.531 kDa
Sequence
MLGVLLVLHGSKIPEWKDVGIKYAEYLSRYFNLVEFGFLEFNKPTLSEALSNLLAKGANKIVVVPLLFATGTHFKRDIPRLLGIDGDEKKIQYMGKEIEIIIADPLGFDEKIGEVLVKRVNETYNKNY

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Length
128 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
14.531 kDa
Sequence
MLGVLLVLHGSKIPEWKDVGIKYAEYLSRYFNLVEFGFLEFNKPTLSEALSNLLAKGANKIVVVPLLFATGTHFKRDIPRLLGIDGDEKKIQYMGKEIEIIIADPLGFDEKIGEVLVKRVNETYNKNY

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)
Length
128 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
14.531 kDa
Sequence
MLGVLLVLHGSKIPEWKDVGIKYAEYLSRYFNLVEFGFLEFNKPTLSEALSNLLAKGANKIVVVPLLFATGTHFKRDIPRLLGIDGDEKKIQYMGKEIEIIIADPLGFDEKIGEVLVKRVNETYNKNY

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Length
128 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
14.531 kDa
Sequence
MLGVLLVLHGSKIPEWKDVGIKYAEYLSRYFNLVEFGFLEFNKPTLSEALSNLLAKGANKIVVVPLLFATGTHFKRDIPRLLGIDGDEKKIQYMGKEIEIIIADPLGFDEKIGEVLVKRVNETYNKNY

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Length
128 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
14.432 kDa
Sequence
MLGVLLVLHGSKIPEWKDVGIKYAEYLSRYFNLVEFGFLEFNKPTLSEALSNLLAKGANKIVVVPLLFATGTHFKRDIPRLLGIDGDEKKIQYMGKEIEIIIADPLGFDEKIGEVLVKGVNETYNKNY

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Length
123 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
13.941 kDa
Sequence
MIGLLLVLHGSKIKEWQEIVINYAEELKRHFPLVEYGFIEINEPKIDEAAKKLVERGADTIVVVPLLFAAGMHFKRDIPNQLKETSNKAKIIIAEPIGFDKRIVDILKEKAEKALSVEGTSYQ

Gene
cbiX
Protein
Sirohydrochlorin cobaltochelatase
Organism
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Length
120 amino acids
Function
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Similarity
Belongs to the CbiX family. CbiXS subfamily.
Mass
13.602 kDa
Sequence
MYGVLLVLHGSKIKEWQDVAIQYANLLRKYFDLVEYGFIEFNQPSITEAAKKLASNGVDTIIVVPLLFAAGTHFKRDIPKQLEEIKGVKIMIAEPIGVDERIAEILKERVEEVLRSSTRS