Protein
Cobalamin biosynthesis bifunctional protein CbiET
Organism
Bacillus megaterium
Function
Bifunctional enzyme that catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7, and then methylates cobalt-precorrin-7 at C-5 to form cobalt-precorrin-8.
Similarity
In the C-terminal section; belongs to the methyltransferase superfamily. Bacterial-type CbiT family.
Sequence
MAIKIIGIGDDGKLSLLPMYEQWIYESDVLIGGKRHLDFFQDFQGEKVAIEGGLSSLVERLKNEEGNAVVLASGDPLFYGIGSYLSTKLDVEIYPYLSSIQLAFSRLKERWQDAYFTSVHGRSIKGLAQRIDGYKKVAILTDEQNSPTALANYLLSFGMTEYKMFVAENLGGETERCQLLSLEEAANQFFSPLNVVILKQVEESPVWPLGIEDDEFIQRKPDKGLITKKEIRTLSISALQLKRDSVVWDIGTCTGSVAIEAAKIAREGQIFAVEKNEADLENCRENLAKFRVDAHTVHGKAPEGLNEFADPDAVFIGGTAGGMETILDVCCSRLNSGGRIVLNAVTIENLAEAMKAFKERGFETAVTLAQISRSKPILHLTRFDALNPIYIITAKRGE