About Products Protein Database Contact

cas10

Gene
cas10
Protein
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A)
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
809 amino acids
Function
When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids.
Similarity
Belongs to the CRISPR-associated Cas10/Csm1 family.
Mass
90.747 kDa
Sequence
MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVWLRDSRNPSQFTDEVDEADIGVSDRRILDAISYHHSSALRTAAENGRLAADAPAYIAYNIAAGTDRRKADSDDGHGASTWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPSPRRIEFDKDRYAAIVNKLKAILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDVSLFDHLKLTGALGACIWHYLQATGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDFIYTIHSSGAAKMLRARSFYLEMLTEHLIDELLARVGLSRANLNYSGGGHAYLLLPNTESARKSVEQFEREANDWLLENFATRLFIATGSVPLAANDLMRRPNESASQASNRALRYSGLYRELSEQLSAKKLARYSADQLRELNSRDHDGQKGDRECSVCHTVNRTVSADDEPKCSLCQALTAASSQIQSESRRFLLISDGATKGLPLPFGATLTFCSRADADKALQQPQTRRRYAKNKFFAGECLGTGLWVGDYVAQMEFGDYVKRASGIARLGVLRLDVDNLGQAFTHGFMEQGNGKFNTISRTAAFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYSGGDDVFVVGAWDDVIEFGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDLEDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYRHIADYFSGNEERGMAFIYKLLELLAERDDRITKARWVYFLTRMRNPTGDTAPFQQFANRLHQWFQDPTDAKQLKTALHLYIYRTRKEESE

Gene
cas10
Protein
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A)
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length
805 amino acids
Function
When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. The active cOA in this bacteria is cyclic tetraadenylate (cA4), presumably made by this enzyme. cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids.
Similarity
Belongs to the CRISPR-associated Cas10/Csm1 family.
Mass
90.302 kDa
Sequence
MLGDGLSVALAGLLHDVGKLYSRARWGERDDQVPDRTHTAYTAHFVREHAGLFRGAGLDPDWLARTASRHHEGWRDRPQYRPETPEEWCVALADTYASKEREEGEGGGSPPEVPLSPPFRRLLLGGEEGREGGYSPVGAGGRVGLEAGGLYPEERPNVSKDVYKRLLERLEGRLEEMARFSLGKEALVLNLALALQETLSLVPSDTQSEPDVSLYDHLRLTAAIAHALWLFHGGSPSAQNLRQDGEKFLLVVGDMGGIQGHIYRIAGAEAGVGGIAKRLRARSLEVSLAAEAMALGLLWRLGLTSLNRILGAGGKFYLLLPNTEEARAALEGTREAWGRWALKRGGSLVPHLAWVAFRGQDFRDFAALLKRLHEALAREKLRPFAFLASTGGVLGAPLRPCAACGLEPARRDEPGSLCPDCEREAALGARLPRSDRVGFFLEEAPRPYLDFPGLKVGLGGPLEGAFHLFRARLDFAPWPDPSEAKPLLGHLPRVEHALKAKGWSLEAYRAWAEEEGLLEDEEPHPEKVLTFAELAALSEGAPYLGALMLDADRMGEAFATGFRREGRDLATPSRLAALSRTLEVFFTTEVLTLLEEPRRYRERLGWDDLEAQRKEARYPLLYSVYSGGDDLFLLGPWDALLDFALDLERLYRLFTRHPRLTLSGGFLLVPPSLPVPELARLLGEAEKRAKAEGRERLFLFGQAVPWETLRGLRAWAEGLRQDLRAERVSRAQVYRWLLLWRRFSPLEDPGERMRYKPLLAYALRRVRERDEEAWKRYLKLLDHQDPAWAYLPVWVQWALYRERRV

Gene
cas10
Protein
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A)
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
800 amino acids
Function
When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csx1, inducing an antiviral state important for defense against invading nucleic acids.
Similarity
Belongs to the CRISPR-associated Cas10/Csm1 family.
Mass
93.633 kDa
Sequence
MGNCNEYTALKIGALLHDIGKFIQRASDKPKSKGHDKFGYEFLKEKFKNGFLNHLDEKTKDKILEIVKEHHNQKIKDDLIGIVRLADWLSSGERREPKGDPENVEVLNTEEQKLLSIFETVCIGELTENLYKNGFKYSLKPLNVSDAIFTDKPYPNENYKELFSKFEDEIKDFKGDVSFEELYQLMQKYTWCIPSVTMWKKAGSLKGGLPDVSLFDHSKTTCAIACCLYQMYVKENKKKNKYAKEYIDDKTLEKLFNNDNGWNKEIFSLIHGDLSGIQDFVFTITTKYATKSLKGRSFYLDFLTEYFAKYICKELNLPITNILFYGGGHFYILSYKVDENLINKLEKEINEVLFNMFRTKIYITIAEVGVTPNDFKKSEDKESKEKTWGFAKKWKEVSEKTVEKKLRRFEYKLEGLFEPYNRGSENRCVICRNEFDKNEKGYAIRENESKSERICDYCASFVALTDILKNFQMEKTIKFNKAYPIIHLTKNKDNLSLQREEFSFLTVKAIEKLESKFRVLSDENYFLKEYKLPHDSGELIIPYKIWAIAFPIIENETEKRILDFDGLAEKAFERTGTRKIGILKMDVDNLGEIFTTGLGNDATISRMSTLSSMLTLFFTGYIPHLIKNEEFEVNGKKYKFKDNIYLVYAGGDDTLIVGAWDAVWELAKRIRGDFKKFVCYNPYITLSAGIVFVNPKFEFKKAVNMAEEELENGKNYIIYEDEETEKKVDKNALTVFNCPMNWDLEVEYNEYCWTKLKSYLEGINKEMVELESLVKKFNEDDLEKNLKKQLKRQIRKESYI

Gene
cas10
Protein
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A)
Organism
Streptococcus thermophilus
Length
758 amino acids
Function
When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP, producing cyclic triadenylate (cA3) up to cyclic hexaadenylate (cA6), which is the active cOA. The enzyme is also able to cyclize pppA3 up to pppA6. cOAs are second messengers that induce an antiviral state important for defense against invading nucleic acids. Synthesis of cOA can occur with AMP plus ATP, 2'dATP or 3'dATP (but no other nucleotides), and requires a free 3'-OH ribose moiety.
Similarity
Belongs to the CRISPR-associated Cas10/Csm1 family.
Mass
86.822 kDa
Sequence
MKKEKIDLFYGALLHDIGKVIQRATGERKKHALVGADWFDEIADNQVISDQIRYHMANYQSDKLGNDHLAYITYIADNIASGVDRRQSNEESDEDASAKIWDTYTNQADIFNVFGAQTDKRYFKPTVLNLKSKPNFASATYEPFSKGDYAAIATRIKNELAEFEFNQAQIDSLLNLFEAILSFVPSSTNSKEIADISLAEHSRLTAAFALAIYDYLEDKGRHNYKEDLFTKASAFYEEEAFLLASFDLSGIQDFIYNIATSGAAKQLKARSLYLDFMSEYIADSLLDKLGLNRANLLYVGGGHAYFVLANTEKTVETLVQFEKDFNQFLLANFQTRLYVAFGWGSFAAKDIMSELNSPESYRQIYQKASRMISEKKISRYDYRTLMLLNRGGKSSERECEICHSVENLVSYHDQKVCDICRGLYQFSKEIAHDHFIITENEGLPIGPNACLKGVAFEKLSQESFSRVYVKNDYKAGTIKATHVFVGDYQCDEIHKYAALSKNEDGLGIKRLAVVRLDVDDLGAAFMAGFSRQGNGQYSTLSRSATFSRSMSLFFKVYINQFASDKKLSIIYAGGDDVFAIGSWQDIIAFTVELRQNFIKWTNGKLTLSAGIGLFADKTPISLMAHQTGELEEAAKGNEKDSISLFSSDYTFKFDRFITNVYDDKLEQIRYFFNHQDERGKNFIYKLIELLRNYESEEKMNVARLAYYLTRLEELTDKDERDKFKQFKKLFFKWYTNNESDRKEAELALLLYVYEIRKD

Gene
cas10
Protein
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A)
Organism
Enterococcus italicus (strain DSM 15952 / LMG 22039 / TP 1.5)
Length
755 amino acids
Function
When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP, producing (mostly) cyclic hexaadenylate (cA6). cA6 synthesis occurs in the Csm effector complex and requires cognate target RNA and ATP; other NTPs are not incorporated. cOAs are second messengers that induce an antiviral state important for defense against invading nucleic acids.
Similarity
Belongs to the CRISPR-associated Cas10/Csm1 family.
Mass
85.841 kDa
Sequence
MNKKLELMYGSLLHDIGKIVYRSNSVDFAKGTHSKIGSQFLNKFKPFQLSGIVDSVSYHHYKELASSSLLDDSVAYITYIADNIASGTDRRASEGDYEGEGNRQRFDKRAPLASIFNVVNSETKGLANYTYSFEKEQVYRYPTDAKKEYTSSQYAALVNKMTDDLSNKLKVGPDSFSSLLQWTESLWSYIPSSTDTNQVMDVSLYDHSKITCAIASCIYDYLTEMNCVNYRKELFSPYEKTKQFYQEDVFLLVSLDMSGIQDFIYNISGSKALKSLRSRSFYLETMLESLVDDLLSDLELSRANLLYTGGGHAYLLLPNTERARDVLASFEGEMKEWFIKIFKTDLSVAIAYKACTGEDLMNSNGTYSDLWQTVSRKLSDKKAHKYSLNEIKLFNSTIHAGTQECKECLRSDIDISEDSLCKICEGIIAISNDLRDYSFFVVSPEGKVPLPRNRYLSVENQDGAERKIKMNKETRIYSKNQPFVGKQLVTNLWMCDYDFSTLNPETKKQGIASYVNREVGIPRLGVLRADIDNLGTTFIKGIPEQYRSISRTATLSRQLSMFFKFELSNILKGARISVIYSGGDDLFLIGAWDDVISKALVLRKAFTRFSAGKLTFSAGIGMYPVKYPISKMASETGVLEDLAKRGEKNQVALWNDSKVFGWSQLEEQILKEKMIPLQEALTNSQEHGKSFLYKMLELLRNEDQINIARLAYLLARSSLSEELTQSIFAWSQNKQQKVELITAIEYLVYQIREAD