Protein
CRISPR-associated endonuclease Cas1 4
Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Function
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Similarity
Belongs to the CRISPR-associated endonuclease Cas1 family.
Sequence
MNIENEVHIENASESKREPKPPEGLLEDDTIYITTPYGKISLDGGRIQVKDSDGEIVASFPLEKVCTMNVFGSASVSTPLLKHCSDKEVVINYFTNFGKYFGSFVPSRNTIALVRRHQAGITKEKSLAICREIIHAKLQNSCVFLARKRVEVPSLLKELRDRSLHAVSVDSLRGIEGEAASIYFPMLSSSLPDEWRSDKRTRRPPRDELNALLSLTYTMVNTEVISALRQYNLDPFIGVMHVDRHGKPALALDLLEEFRPVFCDAFVARLINKRMITKDDFTQGSRLNDTAFKKYLGFYHDFMEESLKHPRFKYSVSRKKAIQIQAIIFRKAICGELKGYYPFIYAR