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carAa

Gene
carAa
Protein
Carbazole 1,9a-dioxygenase, terminal oxygenase component CarAa
Organism
Pseudomonas resinovorans
Length
384 amino acids
Function
Part of the multicomponent carbazole 1,9a-dioxygenase (CARDO), that converts carbazole (CAR) into 2-aminobiphenyl-2,3-diol. Catalyzes the dioxygenation at the angular (C-9a) and adjacent (C-1) positions of carbazole to yield a highly unstable cis-hydrodiol intermediate which is spontaneously converted to 2-aminobiphenyl-2,3-diol. It is also able to attack the angular position adjacent of hetero atom of heterocyclic aromatic compounds such as polychlorinated dibenzo-p-dioxin (DD) and dibenzofuran (DBF). It was also shown that CARDO has the ability to metabolize biphenyl and polycyclic aromatic hydrocarbons, such as naphthalene and phenanthrene.
Mass
43.785 kDa
Sequence
MANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEIDEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPFPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKNYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFEVDEAIVAWRKLASEHNQGIQTQAHVSG

Gene
carAa
Protein
Carbazole 1,9a-dioxygenase, terminal oxygenase component CarAa
Organism
Sphingomonas sp
Length
378 amino acids
Function
Part of the multicomponent carbazole 1,9a-dioxygenase (CARDO), that converts carbazole (CAR) into 2-aminobiphenyl-2,3-diol. Catalyzes the dioxygenation at the angular (C-9a) and adjacent (C-1) positions of carbazole to yield a highly unstable cis-hydrodiol intermediate which is spontaneously converted to 2-aminobiphenyl-2,3-diol.
Mass
42.626 kDa
Sequence
MANQPSIAERRTKVWEPYIRAKLGFRNHWYPVRLASEIAEGTPVPVKLLGEKILLNRVGGKVYAIQDRCLHRGVTLSDRVECYSKNTISCWYHGWTYRWDDGRLVDILTNPGSVQIGRRALKTFPVEEAKGLIFVYVGDGEPTPLIEDVPPGFLDENRAIHGQHRLVASNWRLGAENGFDAGHVLIHKNSILVKGNDIILPLGFAPGDPDQLTRSEVAAGKPKGVYDLLGEHSVPVFEGMIEGKPAIHGNIGSKRVAISISIWLPGVLKVEPWPDPELTQFEWYVPVDETSHLYFQTLGKVVTSKEAADSFEREFHEKWVGLALNGFNDDDIMARESMEPFYTDDRGWSEEILFEPDRAIIEWRGLASQHNRGIQEAR