Protein
MFS-type transporter calB
Organism
Penicillium decumbens
Function
MFS-type transporter; part of the gene cluster that mediates the biosynthesis of calbistrin A and related compounds. Calbistrin A is a secondary metabolite with an interesting structure that was recently found to have bioactivity against leukemia cells. It consists of two polyketides linked by an ester bond: a bicyclic decalin containing polyketide and a linear 12 carbon dioic acid structure (PubMed:30598828). Required for the secretion of calbistrin A and calbistrin C, as well as of related compounds decumbenone A, B and C (PubMed:30598828).
Similarity
Belongs to the major facilitator superfamily. TCR/Tet family.
Sequence
MDEVTRTAQRSPSITETHAGETKLAGPGEKEGDVESPVDPSADSEQNRQQITGLQLFAILASVTLSAFLMLLDGSIIGVAIPNITSQFHSIDDIGWYTAAYQLASAALQPLSGKIYSSFSTKWTYLFFFGLFELGSLICGVANSSSMLIGGRAVAGLGSSGLLNGGMTIIAGAVPLEKRPVYTGIYLGISQLGIVCGPLIGGALTEYTTWRWCFYINLPVGAVTAILLLFLQVPELTEKPRFTFALVRRVIPELDLIGFTLFAPAAIMVLLALYYGGNDFPWDSSQVIGLFCGAGVTIIVFALWERRVGDRAMIPPSMVSHRIVYTSAINGAALVASILVAAQYLPIYFQGVRGYGPAMSGVNTLPGILSQLLTVILSGVLVQKVGYYLPFAAAGSAISAVGNGIVTLFSPTTPTAKWIGYQIVLGSGRGIGMQMGIIAIQNLLPPEKISVGIAFMIFCQNFAGAIFVVVGEVIFTQQLVKQIQAHAPSVKVDAALAAGASSSSLRALVPPGSPELQGVLLAFSNSVDRVFYLLMSLSLAGFVAAFGMGWVDTRKKNKSETE