Protein
E3 ubiquitin-protein ligase brl1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Sequence
MSVVNESRKRRRLIHSEKETRRLDLGEEDDLELFQKEAAWRRSREYEHLTVLEKKLYEYWESLVLKLDHYVAAALENHEQSFEELEKITASLYQPDDNLQTLDLSLAEFSLIKDAQNYLNKYASYFQAHEPTLQKLAKFGSFKLKETPNVHEWIDQRQVHFTSMINYRTSQLKLALLKRKLSFFREALNSAELEWKRVQQDQLTSASERSIENIADDIPASEPKAILENGEGCLNDNDNISKLKNNFQSQADLMQANINSKLDELSQKSTRAAQLYVDIMGITDERVSREPHYLELKGVLSSNEEKIESINRDLSSLFEDIQFFISQRTKRQKDIIDLKLACVKEKQQLIKTLESSLTQIRNERDSLVAKQQMQYTNNLFFDDMMLLLSNLSNARVAILEGYSNRLCIWDRIERSKTGEMNNVLDEKEEISASSALEKLIKNNSCLEAELPSMYAAFDQSQSRLLKKYEELETKEKKALEMHYEKARATQKYFAAMKARDILMTEKKTLKLAENKEHDYIGKLQEREHALTKYESSLKAELEVYKQIKEIYGKHSVEVLTEDKHLQVKQTKLTQKLEDLIESVQKSGEKLMIMHQKLFHLQEEHTILSIKASYNKKESHLINQAYETQEAQVYKGMLKCSVCNFSNWKSKLIPNCGHAFCSNCMEPFYEHKTSTCPQCETPFSVSDILTIHL