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birA

Gene
birA
Protein
Bifunctional ligase/repressor BirA
Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Length
325 amino acids
Function
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
Similarity
Belongs to the biotin--protein ligase family.
Mass
36.123 kDa
Sequence
MRSTLRKDLIELFSQAGSEFISGQKISDALGCSRTAVWKHIEELRKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYQDVISSTQKTAHELANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGIWMSLILRPDIPLQKTPQLTLLAAVAVVQGIEAAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQSDDFPDELKDIATSLSQASGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESYALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETQEGIKKIYSADIELG

Gene
birA
Protein
Bifunctional ligase/repressor BirA
Organism
Bacillus subtilis (strain 168)
Length
325 amino acids
Function
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
Similarity
Belongs to the biotin--protein ligase family.
Mass
36.182 kDa
Sequence
MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEELRKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHELANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAAVAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQPNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESYALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG

Gene
birA
Protein
Bifunctional ligase/repressor BirA
Organism
Escherichia coli (strain K12)
Length
321 amino acids
Function
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
Similarity
Belongs to the biotin--protein ligase family.
Mass
35.312 kDa
Sequence
MKDNTVPLKLIALLANGEFHSGEQLGETLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSLPEPIQLLNAKQILGQLDGGSVAVLPVIDSTNQYLLDRIGELKSGDACIAEYQQAGRGRRGRKWFSPFGANLYLSMFWRLEQGPAAAIGLSLVIGIVMAEVLRKLGADKVRVKWPNDLYLQDRKLAGILVELTGKTGDAAQIVIGAGINMAMRRVEESVVNQGWITLQEAGINLDRNTLAAMLIRELRAALELFEQEGLAPYLSRWEKLDNFINRPVKLIIGDKEIFGISRGIDKQGALLLEQDGIIKPWMGGEISLRSAEK

Gene
birA
Protein
Bifunctional ligase/repressor BirA
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
320 amino acids
Function
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
Similarity
Belongs to the biotin--protein ligase family.
Mass
35.395 kDa
Sequence
MKDTTVPLTLISLLADGEFHSGEQLGERLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSLPEPIQLLDADRIHSQLDSGNVAVLPVIDSTNQYLLDRIGELRSGDACVAEYQQAGRGRRGRKWFSPFGANLYLSMYWRLEQGPAAAIGLSLVIGIVMAEVLRKLGADKVRVKWPNDLYLLDRKLAGILVELTGKTGDAAQIVIGAGINMAMRRVEEDVINQGWITLQEAGITLDRNMLAAKLIYKLRAALELFEQEGLSPYLSRWKKLDNFIDRPVKLIIGDKEIFGISRGIDTQGALLLEQDGVIKPWMGGEISLRSAE

Gene
birA
Protein
Bifunctional ligase/repressor BirA
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
302 amino acids
Function
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
Similarity
Belongs to the biotin--protein ligase family.
Mass
34.342 kDa
Sequence
MMNFTLLTYLADCQPKVRSELEKFSKNLEEDIQQLREIGLDILVDGQDYRLVPMLPLLNPQQISTALFPYSIHYQPIISSTNEWILQNILSLKKGDLCVAEYQTAGRGRRGRQWLSPFAGQIMFSFYWAFDPKKSIEGLSLVIGLAIAEVLNVQVKWPNDILFDERKLGGILVEIANHKNGMLNLVIGIGINVSLSKQTEISQPYAEVCEIDPDVERQTLLPKLIQHLYTRLNIFEQNGIDEEFQQAWQSYNAFSNSEINVLTEQGVISGIEQGIDERGYLKVLCGNKIQMFNGGEVSLRKK

Gene
birA
Protein
Biotin--[acetyl-CoA-carboxylase] ligase
Organism
Paracoccus denitrificans
Length
240 amino acids
Function
Activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins.
Similarity
Belongs to the biotin--protein ligase family.
Mass
24.407 kDa
Sequence
MLARTDSTNAEALKLAPGLSGSAWVLAREQFAGRGRRGREWVMPAGNFAGTLVLRPQGGALAAAQLSFVAALALYDALGLACGPAARLAIKWPNDVLLNGGKVAGILLESSGSGPGVQAVAVGIGVNLAGAPDAGAVEPGATPPVSVQGETGHAVDPEEFLDLLAPAFARWQAQLDTYGFAPIRNAWLARAARLGEPIIARTGTAESHGIFEGIDDSGALILRGPAGRQVIPAAEVFFGG