About Products Protein Database Contact

baiA

Gene
baiA
Protein
3-alpha-hydroxycholanate dehydrogenase (NADP(+))
Organism
Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9)
Length
250 amino acids
Function
Involved in the modification of secondary bile acids to form iso-bile acids via epimerization of the 3-OH group through 3-oxo-intermediate. In vitro, catalyzes the reversible oxidation of deoxycholate (DCA) and lithocholate (LCA) to yield 12-alpha-hydroxy-3-oxo-5-beta-cholan-24-oate (3-oxo-DCA) and 3-oxo-5-beta-cholan-24-oate (3-oxo-LCA), respectively. It prefers NADPH to NADH. Also able to catalyze the oxidation of cholic acid (CA) and chenodeoxycholic acid (CDCA) into 3-dehydrocholate (3-oxo-CA) and 7-alpha-hydroxy-3-oxo-5-beta-cholanate (3-oxo-CDCA), respectively.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.568 kDa
Sequence
MFMMLKNKVAIVTGGTRGIGFAVVKKFIENGAAVSLWGSRQETVDQALEQLKELYPDAKISGKYPSLKDTAQVTAMINQVKEEFGAVDILVNNAGISQSTSFYNYQPEEFQKIVDLNVTAVFNCSQAAAKIMKEQGGGVILNTSSMVSIYGQPSGCGYPASKFAVNGLTKSLARELGCDNIRVNAVAPGITRTDMVAALPEAVIKPLIATIPLGRVGEPEDIANAFLFLASDMASYVTGEILSVDGAARS