atxn2

Gene

ATXN2

Protein

Ataxin-2

Organism

Homo sapiens

Length

1313 amino acids

Function

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.

Similarity

Belongs to the ataxin-2 family.

Mass

140.283 kDa

Sequence

MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPGSRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL

Protein

Ataxin-2: ATXN2

Gene

Atxn2

Protein

Ataxin-2

Organism

Mus musculus

Length

1285 amino acids

Function

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.

Similarity

Belongs to the ataxin-2 family.

Mass

136.485 kDa

Sequence

MRSSTAAVQRPAAGDPEPRRPAGWAARRSLPRTARRGGRGGAVAYPSAGPPPRGPGAPPRGPRSPPCASDCFGSNGHGASRPGSRRLLGVCGPPRPFVVVLLALAPAATPARACPPGVRASPPRSGVSSSARPAPGCPRPACEPVYGPLTMSLKPQPQPPAPATGRKPGGGLLSSPGAAPASAAVTSASVVPAPAAPVASSSAAAGGGRPGLGRGRNSSKGLPQPTISFDGIYANVRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESVLFKCSDFVVVQFKDTDSSYARRDAFTDSALSAKVNGEHKEKDLEPWDAGELTASEELELENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNCSDREGHGPNTRDNKYIPPGQRNREVLSWGSGRQSSPRMGQPGPGSMPSRAASHTSDFNPNAGSDQRVVNGGVPWPSPCPSHSSRPPSRYQSGPNSLPPRAATHTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSMSSGLEFVSHNPPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPRSPRQSSIGNSPSGPVLASPQAGIIPAEAVSMPVPAASPTPASPASNRALTPSIEAKDSRLQDQRQNSPAGSKENVKASETSPSFSKADNKGMSPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLSKNREGEKSRDLIKDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEHKRGPEVTSQGVQTSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFTIHPSHVQPAYTTPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGPKAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL

Protein

Ataxin-2: Atxn2

Gene

atxn2

Protein

Ataxin-2 homolog

Organism

Dictyostelium discoideum

Length

1103 amino acids

Similarity

Belongs to the ataxin-2 family.

Mass

121.136 kDa

Sequence

MSQSKDKKKFVGGGGGGGGNNSGGGGYGSPKHNNNNNNRNSSNNKSPHQSHHNQQHHQQQQQQQQQQQQQQQQPFDSLTAMKERTVFMSMSLVGQNVSVTLKNGDVYEGILHTTSTSTGSSGGGWGVALKMARKKDTNNRVITTLPLPLVIIEAKDFLQITATGVVLDHYRDSFMNRDQQSFITDTELSGFDGNLKERELTPWTPDPSVGESLDDFAANSEAKKPANWDQFETNEKLFGVRTTYEEEIYTTRLDRDSEFYKINQSVAEKKAQEIENEKSGNIHLLEERGFVEGADYDEEERYSSVVRKGLLPTSTTSTTTSPPTQNPTPSSSVYIPPSKRNNNNNTPSTPSVTSPPIVDKKHQQTHQDKKQTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQPTTTATATASTSTSTTTTTNESPSSSSTSSTPSTPSTPKNITTTTATTSTNNTPTATNTNVNSPLGDRESPTISKLRLHQSTIDQDVMGSPRENLSPRSVAYTRYRQILSEPTNKSMNKSGSNISTTPVNGSGNVGPNGTPLLSSVHSDQAPKSPVPTIVSNHGLVKALSLELATPTVPEKFVNDFNNFKLKINNVDRGSETQGLKSFSSNLVIKSKSRPGSPLIGSGSPRPTPTQLSLSGSSTSTNTSTTSPPTTNTTTTTTTATNSTTPSTTEDDKSTTTPITTTILTENKSDDKEKEKEKEKEKVDEKEKEKEKEKSDEKDKDQSSTLVEKKDESSSSSNTTTTTTNTTNNNNNNTTTVTKLSKLKLNPNAKEFVPVVVNKPQPSFKSTTESNTDSVTPINEIYYDSMRKRQLQPESPDQVSLYWVDPFYPRYEEDPYAAAYQMRAHHHMVGHQPPPQLQFNPQFYSQQGHPQLQPHHHMVPPQLQQVPPGVNVHTMKPPGSLQPGGGGVVQPQGIVQPQGIVQPQGGVVQPSAGGAPKTMYQQQQQQQQQTGQPGGPMGVQRGGHLPPQQQPQQQQQQPPPQFIQGIPPGANLVISNGPPNQPFVFQGAHPPYAVPHPQYPMPPQGIQGGNKRFYQPPPQGYPQVQPMIIPQQGQVVSQNSPQQDSPSNRLNQQVPPYSYMTHPPRGYHPNENQYH

Protein

Ataxin-2 homolog: atxn2