Protein
ABC multidrug transporter atrF
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Function
Pleiotropic ABC efflux transporter that confers resistance to azoles such as fluconazole, voriconazole, and itraconazole.
Similarity
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
Sequence
MADGSRLPESATSTTMETNTNEHAKVLSPDAETVPSSSMTATSSELSLDGRWGERDQGEPVSRRGAMEDFEEMRRELTQLSLRRTRSVGKDAHRLRSRASGRASQVHDEEKAIDEEDSTIDGDGDGYQGGFDLGEFLMGGHLERRTTTGEPAKKVGVLFKHLTVKGVETGASFVRTLPDAVVGTFGPDLYRIVCSFIPQLRFGKQPPVRELLHDFTGLVREGEMMLVLGRPGAGCSTFLKTIANDRGAFAGVEGEVRYGGLSAEEQLKHFRGEVNYNPEDDQHFPSLTVWQTLKFSLINKTKKHDKNSIPIIIDALLKMFGITHTKNTLVGNEYVRGVSGGERKRVSIAETLATKSSVVCWDNSTRGLDASTALDYAKSLRIMTDVSKRTTFVTLYQAGESIYELMDKVLVIDSGRMLYQGPANKAREYFVNLGFHCPEKSTTADFLTSICDPNARQFQPGREASTPKTPEELEAVFRNSETYKTICDEVASYEKKLQDTDQEDTRRFQKTVAQSKSRTVSKKSSYTVSFARQVLACVQREFWLLWGDKTSLYTKYFIIISNALIVSSLFYGESLDTSGAFSRGGALFFSILFLGWLQLTELMPAVTGRGIVARHKEYAFYRPSAVSIARVVMDFPAIFCMVVPFTIIMYFMTGLDVTASKFFIYFLFVYTTTFSITSLYRMFAALSPTIDDAVRFSGIALNILVIFVGYVIPKQGLIDGSIWFGWLFYVNPIAYSYEAVLTNEFSDRIMDCAPSQLVPQGPGVDPRYQGCALPGSELGRRGVSGSRYLEESFQFTRSHLWRNFGVVIAFTVLYLIVTVLAAEFLSFVGGGGGALVFKRSKRAKKLATQTTQGNDEEKVQDVGDKAALSRGEAMSASNGESFKRISSSDRIFTWSNVEYTVPYGNGTRKLLNGVNGYAKPGVMIALMGASGAGKTTLLNTLAQRQKMGVVTGDFLVDGRPLGADFQRGTGFCEQMDLHDNTSTIREALEFSALLRQDRNVSKQEKLDYVDQIIDLLELNDIQDAIIGSLNVEQKKRVTIGVELAAKPSLLLFLDEPTSGLDSQAAFSIVRFLKKLSLAGQAILCTIHQPSSMLIQQFDMILALNPGGNTFYFGPVGHDGGDVIKYFADRGVVCPPSKNVAEFILETAAKATTTKDGKKIDWNEEWRNSEQNQRVLDEIQQIREERSKIPVTETGSPYEFAASTMTQTLLLTKRIFRQYWRDPSYYYGKLFVSVIIGIFNGFTFWMLGNSIANMQDRMFSIFLIIMIPPVVLNSIVPKFYINRALWEAREYPSRIYGWFAFCTANIVCEIPMAIVSSLIYWLLWYYPVGFPTDSSTAGYVFLMSMLFFLFMSSWGQWICAFAPSFTVISNVLPFFFVMCNLFNGIVRPYRDYPVFWKYWMYYVNPVTWWLRGVISSIFPTVQIDCSPSETTHFNPPPGQTCANYAGNFITNIAKNGYLLNPDASADCQYCPYSNGAEYMATLNVHDGDKWRCFGIFLAFVIINWLLVYFFIYTVRVRGWSFGMGYLFGGMGLVIDKVKGVFKRKSEKA