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atf7ip

Gene
Atf7ip
Protein
Activating transcription factor 7-interacting protein 1
Organism
Mus musculus
Length
1306 amino acids
Function
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context (PubMed:10777215). Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (By similarity).
Similarity
Belongs to the MCAF family.
Mass
138.593 kDa
Sequence
MDSVEEPQKKVFKARKTMRASDRQQLDAVHRVKGELLRADGKLLNGSHENGDLDPTSPLENTDCIQDREEVNGIDGICFQSEESTTEWKETPCMPNVAVKNKQEDLNSEALSPSITCDLSSRVTTEPGSGSPASDNPGCGTPVSDNPASDNPASDNPASDNPDSGDLAAGELATTVQATGDSACEEPPSSDPSSSDPTSSEPSSSEPTCSEPISGDPVSEEAASHDLVSGDSTCSEPVSGEPVSHEAASSEPATSEPASDEPVARVVAACELAPGESALDDCAPSGDSQSDEPPSSEDSLPRSVCSGLASGELTPGELSVEPATDTVKPSSSAVCEAGPDPDKTEPSSNNSDDCPGKSEDDEHLDQIQSKDSCDEGNKVNSNVVEKEEPLETHSAIICSDLPPENTTKIAEDPIAEPALEEEAISSSMEVDQSEKDEHKSPAEPVAAVSEDPAEEDKEDTVVDNTDSMETDEIIPILEKLAPTEDELSCFSKASLLPVETSQDLEDKMEGSFGSPSKQESSENLPKEAFLVLSDEEDLSCGKDESEAVAQSKMSTPEGEKSEKDGKAEEEERVPAEEQPPVRNEFSRRKRSKSEDMDSVESKRRRYMDEEYEAEFQVKITAKGDINQKLQKVIQWLLQEKLCALQCAVFDKTLAELKTRVEKIECNKRHKAVLTELQAKIARLTKRFGAAKDDLKKRQESPPNPPISPGKPANDTNSNNNMTYRNAGTVRQLLESKRNVSEGPPPSFQTPVNTVSSASHATSTAVVSSQPKLQTSATSGSLPAAPLLPAPSTATVVATTQVPSGTPQPTISLQPLPVILHVPVAVTSQPQLLQSHPGTLVTNQPSGNVEFISVQSQPTVSGLTKNPVSLPPLPNPTKPNIPSVPSPSSIQRNSSTTAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSSSSSRGPIQMKIPISTFSPPSSAEQNSSATPRIVTENQTNKTVDSSINKKAADSTSQSGKASSSDSSGVIDLTMDDEESGTTQDPKKISPPSSSTVSTSQPMSRPLQPILPAPPLQPSGVPTSGPSQATIHVLPTAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPTTQAPLRGTVMQAPAVRQVNPQNSVTVRVPQTTTYVVNNGLTLGSAGPQLTVHHRPPQVHNEPPRPLHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQSQNGIVLSWSVLEVDRSCATVDSYHLYAYHEEPSATVPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTDVISSSQNS

Gene
ATF7IP
Protein
Activating transcription factor 7-interacting protein 1
Organism
Homo sapiens
Length
1270 amino acids
Function
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100).
Similarity
Belongs to the MCAF family.
Mass
136.394 kDa
Sequence
MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKETPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGELASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPAEVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVNSNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDDEESGASQDPKKLNHTPVSTMSSSQPVSRPLQPIQPAPPLQPSGVPTSGPSQTTIHLLPTAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPPAQAPLRGTVMQAPAVRQVNPQNSVTVRVPQTTTYVVNNGLTLGSTGPQLTVHHRPPQVHTEPPRPVHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQSQNGIVLSWSVLEVDRSCATVDSYHLYAYHEEPSATVPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTDVISSTQSS

Gene
ATF7IP
Protein
Activating transcription factor 7-interacting protein 1
Organism
Gallus gallus
Length
1085 amino acids
Function
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity. May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity).
Similarity
Belongs to the MCAF family.
Mass
117.377 kDa
Sequence
MDNTDEPQKKVFKARKTMRASDRQQLEAVYKAKEDLLKTTEVKLLNGKHENGDSDLNSPLSNTDCTEDKREVNGLVDSNEISEIKRPESRAESVVSDLEPKPLSPVNVTREQDTDVALVCEAENRVLGSNKVNFHEENNIKNRLDQRESDTPSGENKSNCDNSFSPEEKGKTNDITIISNSPVEEKKKAGEIIVEDTVGEEAISSSMETDQEPKNERDGTAGLSETVVEKAVDESSESILENTDSMEADEIIPILEKLAPAEDEMSCFSKSALLPVDDTAPDLEEKMDNCLSSPLKQESNESLPKEAFLVLSDEEDPCDEREHAEVILPNKSGLPEEVEKSEEEDKEREVVHKEEEKHTERGEVSRRKRSKSEDMDSVHSKRRRFVGEEDYEAEFQVKITARRDVDQKLEKVIQRVLEEKLAALQCAVFDKTLADLKMRIEKVECNKRHKTVLTELQAKITRLTKRFGAAKEDMKKKQENTPNPSLSSGKAASSTANANNLTYRNITTVRQMLESKRNVGDSKPATLQAPVSAAPASSLAAPQTPASGHPKPQTPVTSSPLTTTVISTANTATVVGTSQVPSGSTQPMSVSLQSLPVILHVPVAVSSQPQLLQGHAGTLVTNQQSGSVEFISVQSSSTVGSLTKTAVSLASTNTTKPNNSPSVSSPGVQRNSPASAGSVRTTLAVQAVSTTHPVAQTTRTSLPTVGTSGLHNSTSSRGPIHMKIPLSAFNSTAPTEPPTITAPRVENQTSRPPTDSSANKRTAEGPTQSVKVTGSDSGGVIDLTLDDEDDVSSQAEAKKQNQTASTAQSIPTQPLSRPLPPLQPNPLQQTGVPTSGPSQTTIHVLPTAPTTVNVTHRPVTQTAAKLPIPRTPTNHQVVYTTIPAPPAQNSVRGAVMPSPSLRPVNPQTGSMTVRMPQTTAYVVNNGLTLGSGAPQLTVHHRPPQVHAEPPRPVHPAPLPEAPQPPRLPPEAANTSLPQKPQLKLARVQSQNGIVLSWSVIEVDRSCASVDSYHLYAYHEDPSATMPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTDVISSQSS

Gene
atf7ip
Protein
Activating transcription factor 7-interacting protein 1
Organism
Danio rerio
Length
815 amino acids
Function
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity. May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity).
Similarity
Belongs to the MCAF family.
Mass
85.267 kDa
Sequence
MEVAVPEEPQKKIFRARKTMKMSDRQQLEVLHNTLATTNSSLSSSPPQTPLMNGTHTETEKDLNNKEGDLMAPATDSARCSPSPSFPVSRSPSPPNTQTTSPAMDLEDPLVATEEKKETSNKSSSSSPSASPAGLNCDPEVKEGFLCLSEEDETQADKDEKDSSEEKMNVDAETEDQKEEKDEKDTDTPENAEDNSAPVGLKRTLSEEKDEDDKEIEEERDGKRARLEGEELEAQLELKITANGGNRDKIEKMVQQLVEERLRVLQLTVFDRSLKELKDRVEKIDNVTKQQNALQHINTLQAKISRLAKKFGAANQASENAKRTQDAQAAAAAAQANNATNATTPQRTVKTTVDSKLSSSPTVSNSTAVPAQPKPLSTPATPTSSALATTAPILQIISTTTSSTPSSTSLPGQSQTGTLLLKTGPNPTVMTNAPATSGGQPVAMQQLLIQLPLAMANGQSGALVNAAGGVGLIPVSSLSTVSNINKAKTTTPATTFMLQKTAGNVSSATSSAPAVSLARAVYPGGTGTVSSPNTGISVTTARTPTQCAAVVGVSTAAASPGTTGPAATGSAAAAAGSPSASALASKTDNQASTPKTASQPGRPKGSVIDLTEDDDDVQVTGVQKATVSPVTTQRSSGPPPLVSSTPNTGTGVRSAQRSTVDSPSQSRPSSSSSTSLPPLPLAPSPPARLPPEANHTSPPQQPQLKLARVQSQNGIVLSWCVAETDRNCAAVDTYHLYAYHQDHQSSVSGASAQMLWKKIGEVKALPLPMACTLTQFVSGSTYYFAVRAKDVYGRFGPFCEPQCTDVITPASSAST