Protein
Acid-sensing ion channel 1A
Function
Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.
Sequence
MKTSVMDLKVEPMDIDFDQPPPLQVFAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHVTKLDEITTPVMVFPAVTICNLNSIRFSRITRNDLYHAGELLALLNSRHEVREAHLVEESVMEVLKSKTDFRSFKPRHFNMWEFYNRTGHDIKDMLLSCQFRGSPCRPEDFSVVFTRYGKCYTFNSGETGPPRVSVKGGMGNGLEIMLDIQQDEYLPVWGESDESSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLVYLPAPWGSCKSTPPSSDYFRAYSISACRTDCETRYLVENCNCRMVHMPGDAPYCTPVLYKECAHPALDFLVETDSDYCSCETPCNITRYSKELSFVKIPSKASVKYLAKKYSKSEKYITENVMVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYLYEVMKYRLCRCSNKKHHNNNNNTDHNAVFSLDDVNCHVSKFH