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arpp19-a

Gene
arpp19-a
Protein
cAMP-regulated phosphoprotein 19-A
Organism
Xenopus laevis
Length
117 amino acids
Function
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.
Similarity
Belongs to the endosulfine family.
Mass
12.931 kDa
Sequence
MSGENQETKAQEESSALEQKEIDDKVVSPEKSEEIKLKARYPNLGPKPGGSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPTAASDKTEVTGDHIPTPQDLPQRKPSLVASKLAG