Protein
Pentafunctional AROM polypeptide 1
Organism
Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Function
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
Similarity
In the C-terminal section; belongs to the shikimate dehydrogenase family.
Sequence
MAEPTKISILGRESIVADCGIWGTYIVQDLLTNLPSTTYVLVTDTNLGSIYREKFAKIFNEAAAALSPAPRLLTKEIPPGENSKSRQGKADIEDWMLQQTCGRDTVIIALGGGVIGDLLGFVAATYMRGIRFVQVPTTLLAMVDSSIGGKTAIDTPLGKNLIGAIWQPHRIYIDIDFIDTLPEREFINGMAEVIKTAAISDEKEFAALEQHADAILKAARSKPGKGRFDLVRQVVKDRIVASARHKAFVVTADEREGGLRNLLNLGHSIGHAIEAILSPQVLHGECVAIGMVKELDLARYLGILKPVAVSRMVKCLSKYGLPTSLKDSRVRKHTAGKHCSLEQMMANMALDKKNDGPRKKVVLLSAIGQTYEPKASVVSNEDIRAVLAPSIEVIPGVPKDLNVVCAPPGSKSISNRALVLAALGSGTVRVKNLLHSDDTEVMLNALERLGAATFAWEDEGEVLVVNGNGGKMQASPTELYLGNAGTASRFLTSVATLSGKGSVDYNILTGNNRMKQRPIGDLVDALTINGAQVEYLEKAGSLPLKIAASGGFKGGRINLAAKVSSQYVSSLLMCAPYAKEPVTLKLVGGRPISLSYIEMTTAMMRSFGIDVQKSTTEEWTYHIPQGSYNNPPEYVIESDASSATYPLAIAAVTGTTCTVPNIGSASLQGDARFAVEVLRPMGCKVEQTATSTTVTGPADGVLRPLPNVDMEPMTDAFLGASVLAAIAQGEGGNHATRIYGIANQRVKECNRIEAMRVELAKFGVVCREHPDGLEIDGIDRSTLRHPAGGVFCYDDHRVAFSFSILSLVAPTPTLILEKECVGKTWPTYWDALKQKFGVSLKGKELAESEITHGPADRSDASIVIIGMRGAGKTTTGRWAAKALNRKFIDLDVELEQTEGKTIPDLIKERGWKGFRDAELSLFKRALTERPTGHVFACGGGIVEIAEARNILIDYHKNKGNVLLVMRDIKKVMEFLNIDKTRPAYIEDMMSVWLRRKPWYQECSNVQYYSRHSSSPELALAMDDFDRFIQFVSGKTDYLAAIRRKRLSFFMSLTLTDLRDSGDLLRTVASGSDAVELRVDLLKDPSSGNGIPSAEYVAEQISFYRSRVSLPIVFTIRTVSQGGKFPNDAHDAALELIMLAIRSGCEFIDLEITFPEDLLRKVAESKAHAKIIASHHDPQGKLNWANGSWIQYYNKALQYGDIIKLVGVAETLKDNTALREFKDWAEQAHPDVPVIAINMGDKGQLSRMLNGFLTPVSHPALPFKAAPGQLSAAEIRKGLSIMGEIPAKKFAIFGKPVSVSRSPAMHNTLFEQNGLPYVYTRLETDQAQDVKEFIRSPDFGGASATIPLKLDIIPLIDEVLNEAEIIGAVNTIIPVEGKDGSTRLIGRNTDWSGIVRCLREAGAHSNEGESSALVIGGGGTARAAIYALHNMGFSTVYVLGRSPEKIQNMASTFPTGFDIRVLENASDIENIPRVAVGTIPGDRPIEANMREILCTIFERSGRAADGKSAAVLLEMAYKPSVTPLMQLASDSGWTTIPGLEALVGQGVYQFEYWTGITPVYEVARNAVLGTDETK