Protein
Pentafunctional AROM polypeptide
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
Similarity
In the C-terminal section; belongs to the shikimate dehydrogenase family.
Sequence
MAEPISNPTRINILGKDNIIIDHGIWLNFVAQDLLQNIKSSTYILITDTNLYKTYVPPFQSVFEKAAPQDVRLLTYAIPPGEYSKGRDTKAEIEDWMLSHQCTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQCPTTLLAMVDSSIGGKTAIDVPMGKNLIGAFWQPERIYIDLTFLNTLPVREFINGMAEVIKTAAIWDENEFTALEENAKAILEAVRSKNKSADRLAPIRDILKRIVLGSARVKAEVVSSDEREGGLRNLLNFGHSIGHAYEAILTPQVLHGEAVAIGMVKEAELARFLGVLRPSAVARLSKCIASYDLPTSLQDKRIVKLTAGKECPVDVLLQKMAVDKKNEGRKKKIVLLSAIGKTYEPKASVVEDRAIRIVLSPCIRVFAGVPKDLNVSVTPPGSKSISNRALILAALGEGTTRIHNLLHSDDTQVMLNAVAQLQGASFSWEEGDVLVVKGNGGKLQATSTPLYLGNAGTASRFLTSVAALCNPSDVNSTVLTGNARMKQRPIGALVDALRANGVGVKYLEKEHSLPVQVDAAGGLAGGVMELAATISSQYVSSLLMAAPYAREPVTLRLVGGKPISQPYIDMTIAMMASFGVQVQRSAEDPNTYYIPQGTYKNPETYVVESDASSATYPLAIAAITGTTCTVPNIGSKSLQGDARFAIEVLRPMGCTVEQTDVSTTVTGPPIGTLKAIPHVDMEPMTDAFLTASVLAAVASGTTQITGIANQRVKECNRILAMKDQLAKFGVHCNELEDGIEVIGIPYTELKNPTEGIYCYDDHRVAMSFSVLSTISPHPVLILERECTGKTWPGWWDTMSNYFKVHLEGEEEPHSSHVSHEKPRKGNPKSIFIIGMRGAGKSTAGKWMSEVLNRPLIDLDHELERREGQTIPEIIRSERGWEGFRKAELELLEDVIKNNPTGHIFSCGGGIVETEAARKMLLSYSQNGGIVLLVHRDTDQVVEYLMRDKSRPAYSENIREVYYRRKPFFEECSNFRYYSPHPDGSKALTEPPFDFSQFLSVICGHSNHLEEVKKKPHSFFVSLTVPNVSKALDIIPKVVVGSDAVELRVDLLEDYDPEFVAKQVALLRSAARIPIVYTVRTVSQGGKFPDDDYELALKLYRTGLQAGVEYLDLEMTMPDEVIEAVTNEKGYTHIIASHHDPKATLSWKNGGWIQYYNKALQHGDVVKLVGVARELADNFALARFKASLAAAHDKPLIALNMGAAGKLSRVLNGFLTPVSHPALPSKAAPGQLSAAEIRQALALIGELEPRSFHLFGNPISASRSPALHNALFRDNGLPHQYSLFETDNAADVKDLIRAPGFGGASVTIPLKLDIMPLLDEVSDAAKVIGAVNTIIPVRNGDKVTLRGDNTDWMGMVYALRNAGVVKCTKESPTAGMVVGAGGTTRAAVHALHDLGFAPIYVVARNADRVKALAESFPAEYDIRSLSTPEEVAAESTAQPSVVISTIPADKPIDQSMREVIVASLRHPSVADGKHVLLEMAYTPRHTPLMQLAEDAHWQTIPGLEVLAAQGWYQFQLWTGITPIYTDAQAAVMGN