Protein
HECT-type ubiquitin ligase-interacting protein apyA
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Function
May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability.
Similarity
Belongs to the arrestin family.
Sequence
MALHRLKGHGANVGNRVGIQLDKDFVLFQGSEQEALAVYLSGILSLRLKETTTIKYIRLHLRGVRRVSSDTQSSLPARTGRKRFCSENEFYSRTWNFFDGYREAPMTVPAGEYKYPFDVVMEGSLPASVEGMKEASISYLFTVEIGRRHGRDITFDKPLRVIRVPDLEPCSHDFALDEVWANKIAYRIGIQNRTVALGTRIDVDYVFAPLLRDMKIAFIESQLLEVRDLSVEPNDGGSAHAARTETIVCSDRYTLGEEYSSKALESYQFSRTLQLPQALGHCVQDTEDMGVRVSHKLKIHVRMHNPDGHESELRLAIPVLIYLSPYYRVWEDSFCGETIPLPETLNPSDECPPAYGMHELDQLYMPQD