Protein
Autophagy-related protein 18
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct apg-7/atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).
Similarity
Belongs to the WD repeat SVP1 family.
Sequence
MTGGTLNFITFNQDYSCLAVGTSKGFRFYHTDPFSKIFSSDEGNVSIIEMLFSTSLVALILTPRQLEIQNTKRASVICELTFPSAVLAVRLNRKRLAVVLECQIYLYDVSNMNLVQTIDTSPNPNAICALSPSSDSCYLVYPRPNPREDVGAKAPAHLPPPSQYVPPKRGDVLVYDALNLKTVNVVEAHKSPLCAIALNHDGSMLATASETGTIIRVFSLPQGQKLFQFRRGTVPTSIYSMSFNLSSTLLCVSSTSDTVHIFRLLNTQKNANALPGGGPAQGTRSRSFDVNDPSPHKGEVPSAGNGNNGSGSHKREPSGSFGNMLRRSSQMMVRGVAGVASSYLPQSVAEMWEPERDFAFIKIPKSSNNRAGGLSATPLRSVVAMSSSSPQVMVVTSDGGFYVYNIDMEKGGEGYLVKQFSVLDGDDKLTNSDYGA