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alt3

Gene
alt3
Protein
Cytochrome P450 monooxygenase alt3
Organism
Alternaria solani
Length
509 amino acids
Function
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of alternapyrone derivatives (PubMed:16356847). Alternapyrone is a decaketide with octa-methylation from methionine on every C2 unit except the third unit (PubMed:16356847). All the domains in the polyketide synthase alt5 are apparently involved in alternapyrone synthesis, that is, the 8 CMeT, 7 KR, 7 DH, and 4 ER reactions in the 9 KS-mediated condensation steps required for alternapyrone synthesis (PubMed:16356847). the alternapyrone produced by alt5 might be intensively modified by cytochrome P450 monooxygenases alt1, alt2 and alt3 and FAD-dependent oxidoreductase alt4 present in the alt gene cluster (PubMed:16356847).
Similarity
Belongs to the cytochrome P450 family.
Mass
57.907 kDa
Sequence
MALSSALDSLWHQLDQLLSLINRNIITGIIVLPVLYVLLKVIYNLYLSPLAGYPGPKLWAVSRLPWNRANMKGRISWKIRELHDKYGPVVRIAPDELSYTTSGAWKKIYGQRNPEFVKALDGRGIAPASIGGQRSLMTEHQDKHLRLRRAIDPAFSQRALREQESYFQDHSDNLVQKLKQRCKDGPLDMTTWYNLVAFDIVSDLAFGEPSGCVNNPDQPWIQAILARAKAIVWFQLAVQYGFMGLLNWMTPKYVTESRKKHIAMTEAKLKARVEAKNPGKDFMSYILENDEKLNHLELVMLSSNFIVAGSGTSAGGMSGLTYLLLRNPDKLEKLKQEIRGLFKSRADMTLQAVTSCKYLRACLNEGMRLYPPTPGSLPRFVPGKGEMIEGKWVPGGYAVGVNQLAAGHSERNFKKAREFHPERWLDEPDSEFKDDDRSAVQPFSYGQRGCIGRSMAYAEMSLTMAKLVWYFDWELDEPDNDWWNQQGTYLVWEKLPLQVKLTPVSDVVE

Gene
ALT3
Protein
Acyl-acyl carrier protein thioesterase ATL3, chloroplastic
Organism
Arabidopsis thaliana
Length
190 amino acids
Function
Acyl-ACP thioesterase involved in the production of fatty acids and beta-keto fatty acids. Can produce fatty acids of long chain (14:1 and 16:1) and beta-keto fatty acids of medium to long chain (8:0, 10:0, 12:0, 12:1, 14:0 and 16:0) when expressed in a heterologous organism (E.coli). Possesses thioesterase activity for lauroyl-ACP (12:0-ACP) in vitro. May play a role in the generation of long fatty acids in the chloroplast.
Similarity
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
Mass
21.54 kDa
Sequence
MFLQVTGTATPAMPAVVFLNSWRRPLSIPLRSVKTFKPLAFFDLKGGKGMSEFHEVELKVRDYELDQFGVVNNAVYANYCQHGRHEFLESIGINCDEVARSGEALAISELTMKFLSPLRSGDKFVVKARISGTSAARIYFDHFIFKLPNQEPILEAKGIAVWLDNKYRPVRIPSSIRSKFVHFLRQDDAV