Protein
Non-reducing polyketide synthase afvB
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Function
Non-reducing polyketide synthase (NRPKS); part of the gene cluster that mediates the biosynthesis of aflavarin, a bicoumarin that exhibits anti-insectan activity against the fungivorous beetle C.hemipterus (Ref.2, PubMed:26209694). Catalyzes the formation of the aromatic polyketide from acetyl coenzyme A and seven malonyl coenzyme A molecules (PubMed:26209694).
Sequence
MRIFHFSNKFPPDDLADLFRRLRLHSKCPNHVILARVLEEVTDVVREEIAELPAELRSLLPPFQSILDLAESFNWHQGPLSGTFECVFLVLMPVCLFVGRPDEFVFRRDTSLFTGLGLGFLAATAIVASPSLCSVPVTVAEVVRMAMRTGLLIYQRSQDLEPQSLDGALESWTSIVKGMGEVAVREGIDEYNSSTDTPQPSSIYISVVEPDGSVFINGPPSRLRKFFSTSGKVQSAAHAPLPVYGGPCHAPHLYDHSHSSWAVKKCRAKVLSRDLSHAAYLLSMADGNPLKADTVLELFESATYILLTSIIRWGDVVNAITASSPLLEKDMKLQVEILRPSPVVDGLVSAIQKSHPGCSAYVVDLGEWIFDDTHISPHGAHEKIAVIGMSCRLPGGADDLELLWELLREGRDVHRKVPADRYDVDSHTDITGKQRNTSHTPFGCFVDQPGLFDAGFFDMSPREAGQTDPTHRLALLTAYEALEQSGYVPDRTRSTRRERVGTIYGQCSDDYRECNAGQDIDMYFIPGNYRAFAPGRISYFFKFSGPSFNIDTACSASLAAVQIACSVLSRGEADMVVAGGLNILTGSDSFAGLSKGFFLSKTGNCQVFDDAADGYCRGDGIGSIILKRLSDAQQDNDNILGLILGSATNHSSNAISITHPHAPTQANLYRSTLMQAGVRPQDVDLVEMHGTGTQAGDAAEIESVTKVFSPAVPRRSQPLRISSVKANVGHGEAAAGITALIKALLIFKHNEIPPQVCLRTTLNSKFPDLRQLNVHIPKKIIPWPRLPGRKRYIMVNNFSAAGGNTSLLLEEPPARPDPKGCPQTRFVVTVSAKSTVSLIRNLEGLLGFLKMDPFVDLASLAYTTTARRMHHKYRIVVHGASIQEIVKSLEQHISIAETQCAIQKAPTIGFVFSGQGSFSQGVGRQLFQEYPPYRNEIQRLDEICTSHGFDSILPAITSRSSDILEISPFMAQLVTVCVQIALCRLWRSLGVIPNVVVGASLGEYAALYAAGTLSASDVIYLVGQRARLMQELCTINSHSMLAVKATIGEIRHTVRNNAYEFACINGPRDVTLAASVEDINDIQQTLVSQGYRVAKLNVPFAFHSSQIEPILEPYNKIAHSVIFRNLKTALISPLLSDVVFDNKSFPPSYLRDSTRGTVQFSDAMTKAQEIGLVDSKTVWVEIGVHQTYTGAMRANIPNLEVVAPSLRSDESNWHTLAASMSALHSAGVHLDWNTWYKPFESQLRLLNLPPYQWNLKNHWIQHNGDWLLLKDKRSRTGYERSPAPAPPPLRTALVHHILEESFGKDGGTVVIQSNVTDDEFHAVASGHQMSGRPLVSVFAYTDIALIMARYMYSRLKSGTELSAMDFGKVRVFQGLIPRKDRSKPQYVRMRMQADPMCSSMPLSLHRVLDDEMNEEELAIGVVTCGDSHSWRDEWAAYSYLLTSRIEALHQLADQGLASRVSKDLVYTLFKNVVDYAEHYRGIQSAVMYGLEAVADVILSPSQDSRWTAPPHHIDPITHVGGLILNAGPAMDHTNTIYIMEGWESMRFSDSLMAGELYRSYVKMNPANDNSGFFSGDVYILHGNRVIGRVREMTLRPLPRILMSRFFDPPDSQYGQMAQQEPSTALPSTPQHTSSAKTTESTPSQQDESDNTSLATPENENKAPISGSWPNANSQLVRDAIALIASETGVEPDALTDETEFSAVGVDSLLSLVLVEKFALELNIDLQGSFFLETPNVCDLKAYLEGNQMTLR