Protein
MFS efflux transporter aclA
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Function
MFS efflux transporter; part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells (PubMed:25302411).
Similarity
Belongs to the major facilitator superfamily.
Sequence
MDQPSPSAEDSQPERQSTGTRGTRFWAVFVSLCFASFVASLDITAITTALPTVTRELDGGENYVWIANSYTLASAVVQPLIGQISNIVGRRNPMIILMCLFALGSGICGGATSTGMMIAGRTVQGLGAGGILLLLEVIVCDLVPLRERAQYVGIALSTCALGISLGPLVGGALVQHATWRWVFYINLPCAGVALVALVLCLNVQHKREVSWGRALARVDWVGNTIFIAAICAIMYALVIGGSVHPWSSYQVLVPLVLGAFGWVLFHIFEASPYCLEPTMPPRLFRNRTSMTAYVLAFLAAMLMQWVVYFLTLFFQTVKGQSTTMSGVDVIPFTGFMIPSAIVGGAIMSKTGVYRPLHWAGFALLSICMGVFSTWDAGTPRAEWVILQCLVGLGHGLLLTSVLPAIQAALPESDNAAATSAYAFLRSFGFVWGVEIPAVVFNGQVDRFISRVHDATVRNKLAHGGAYSLAGTSFLSQLGDEADAVRSTYTDSLRTVWQVGMAFALLGFALVVVEKHIELRTTLETDFGLEGSENRAATSVEGVETGPVSKAQ