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acat1-b

Gene
acat1-b
Protein
Acetyl-CoA acetyltransferase B, mitochondrial
Organism
Xenopus laevis
Length
420 amino acids
Function
This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.
Similarity
Belongs to the thiolase-like superfamily. Thiolase family.
Mass
44.073 kDa
Sequence
MAFCGPRTAARLSHSTRALHYTHRSFASPRTLNEVVIASAARTPIGSFQGTLSSLPATKLGSIAIKAAVERAGIPADEVKEVYMGNVLQAGQGQAPSRQATLGAGLAISTPTTTINKVCASGMKSVMLAAQSLMCGHQQVMVAGGMESMSNVPYCMSRGATPYGGVKLEDIIVKDGLTDVYNKFHMGNCAENTAKKLSISREEQDGFAITSYTRSKAAWDSGLIANEIAPVTIAQKGKPDIIVQEDEEYKRVDFSKFPKLKTVFQKDNGTVTAANSSTLNDGAAALVLMTAEAANRLNVTPLARIVAFADAAVDPIDFPIAPAYAIPKLLSEAGLKKEDIAMWEINEAFSVVVLANIKMLDIDPARVNVNGGAVSLGHPIGMSGARIVGHMAHALRKGQFGIAGICNGGGGASAVLIEKL