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abcA4

Gene
Abca4
Protein
Retinal-specific phospholipid-transporting ATPase ABCA4
Organism
Mus musculus
Length
2310 amino acids
Function
Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP. Transports preferentially phosphatidylethanolamine. In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
Similarity
Belongs to the ABC transporter superfamily. ABCA family.
Mass
260.209 kDa
Sequence
MGFLRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSQHECHFPNKAMPSAGLLPWLQGIFCNMNNPCFQNPTPGESPGTVSNYNNSILARVYRDFQELFMDTPEVQHLGQVWAELRTLSQFMDTLRTHPERFAGRGLQIRDILKDEEALTLFLMRNIGLSDSVAHLLVNSQVRVEQFAYGVPDLELTDIACSEALLQRFIIFSQRRGAQTVRDALCPLSQVTLQWIEDTLYADVDFFKLFHVLPTLLDSSSQGINLRFWGGILSDLSPRMQKFIHRPSVQDLLWVSRPLLQNGGPETFTQLMSILSDLLCGYPEGGGSRVFSFNWYEDNNYKAFLGIDSTRKDPAYSYDKRTTSFCNSLIQSLESNPLTKIAWRAAKPLLMGKILFTPDSPAARRIMKNANSTFEELDRVRKLVKAWEEVGPQIWYFFEKSTQMTVIRDTLQHPTVKDFINRQLGEEGITTEAVLNFFSNGPQEKQADDMTSFDWRDIFNITDRFLRLANQYLECLVLDKFESYDDEVQLTQRALSLLEENRFWAGVVFPGMYPWASSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGIVKSQMQAEPPIGVYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMALSIFLLTLFIMHGRILHYSDPFILFLFLLAFATATIMQSFLLSTLFSKASLAAACSGVIYFTLYLPHVLCFAWQDRMTADLKTTVSLLSSVAFGFGTEYLVRFEEQGLGLQWSNIGKSPLEGDEFSFLLSMKMMLLDAALYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEEMEDPEHPEGMNDSFFERELPGLVPGVCVKNLVKVFEPSGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLIGGKDIETNLDVVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRGGCEGVCSCTSKGFSTRCPTRVDEITEEQVLDGDVQELMDLVYHHVPEAKLVECIGQELIFLLPNKNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDAGAGSMFVGGAQQKREQAGLRHPCSAPTEKLRQYAQAPHTCSPGQVDPPKGQPSPEPEDPGVPFNTGARLILQHVQALLVKRFHHTIRSRKDFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQYTFFSMDEPNNEHLEVLADVLLNRPGFGNRCLKEEWLPEYPCINATSWKTPSVSPNITHLFQKQKWTAAHPSPSCKCSTREKLTMLPECPEGAGGLPPPQRTQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPAIPISGEALVGFLSGLGQMMNVSGGPVTREASKEMLDFLKHLETTDNIKVWFNNKGWHALVSFLNVAHNAILRASLPRDRDPEEYGITVISQPLNLTKEQLSDITVLTTSVDAVVAICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWLTNFLWDIMNYAVSAGLVVGIFIGFQKKAYTSPDNLPALVSLLMLYGWAVIPMMYPASFLFEVPSTAYVALSCANLFIGINSSAITFVLELFENNRTLLRFNAMLRKLLIVFPHFCLGRGLIDLALSQAVTDVYAQFGEEYSANPFQWDLIGKNLVAMAIEGVVYFLLTLLIQHHFFLTRWIAEPAREPVFDEDDDVAEERQRVMSGGNKTDILKLNELTKVYSGSSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTSISDVHQNMGYCPQFDAIDDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGNKRKLSTAIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGTFQCLGTIQHLKYKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHHSMLQFQVPSSSLARIFQLLISHKDSLLIEEYSVTQTTLDQVFVNFAKQQTETYDLPLHPRAAGASWQAKLEEKSGRLQTQEPLPAGSEQLANGSNPTAAEDKHTRSPQ

Gene
ABCA4
Protein
Retinal-specific phospholipid-transporting ATPase ABCA4
Organism
Homo sapiens
Length
2273 amino acids
Function
Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylethanolamine (PubMed:24097981). In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
Similarity
Belongs to the ABC transporter superfamily. ABCA family.
Mass
255.944 kDa
Sequence
MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQHLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYLLINSQVRPEQFAHGVPDLALKDIACSEALLERFIIFSQRRGAKTVRYALCSLSQGTLQWIEDTLYANVDFFKLFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVTRPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILNFLYKGPRESQADDMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHPRAAGASRQAQD

Gene
abcA4
Protein
ABC transporter A family member 4
Organism
Dictyostelium discoideum
Length
1615 amino acids
Similarity
Belongs to the ABC transporter superfamily. ABCA family.
Mass
182.397 kDa
Sequence
MESIKNQLIPLLKKNWTLKGKSKIKLLLEILLPLISIGILFGILYLSMIITRDFKERPASGFAFDIAHTKQLLIGSNGGLNSDQRNILDNLKLQVSIQHPEFSNDYINRCFVEFKDIESMDEYFHDPFNYRGVMGGVWFPDDSFNGNTIKYSIRVDSDFTHDNTQQFQDREDSQIYLRHYFTQIQTGVDQAILLTNQIAIPIFATGQRFPNPYISFWEKWTDGRKLILLNTGGVFITASLFATLFTLITNIVIEKETKILEGMKTMGLNSFAYYISNSIISLITLLSSTLLVSIILSASQLVHHVKWITLILILIPYSITLLLIAFILCKFFTKSKYAGLMAFLIVLLLSGIGIIIGRFNISPTLKLLSCLFSPIAISVANYVWCYKDLIVFKEVDINVNMVNEYEIIGMLVFDIFLYILILWYLDNVITGEYGIPKKWYFFLTKNYWRKNKKSNINNNGVFDVEATSCNRNSSYNEKNFEKIEHQLERPTISIRNLRKEFKTGDGNRIAVNDLSIDMYKNRIHSFLGPNGSGKSTTLSMLTGMIEPTSGDALINGFDIRNNIDEIRKHLGVCPQSDIIWEQLTVMEHLEFYAALKGFTNSNQRKVEATKIALEVGLGEKLNAPAGTLSGGQKRKLCLAIAFIGPNSDIILIDEPTSGLDASNRRLIWDFILKYRENKTIILVSHYLEECDILSNTISIIANGELKCNGSSLFLKNRFGVGYLLTISKEHNSINNSNLTKTISDIIFNHIPKGSLLSDAGTELCFRLPNESIGNFSNLFKELDDRKKQLSIENYGISITTLEEVFLKIISNSETNPNFNQSVLNTALKTNSSGIKSYQQLKGLLIKRVKTSRKDIKSFVLSILIPILILAGGLILYKNMRTIDIYNTVTQPLILDFNVYGKSVTPVSIDKVNETMTSLFDNSIGHSDRTTLVPYDELHDYLIHHYFGVPGALYFDFRYFKNVKFLHYNVFFNKDYLHALPIYINFVDSEILRSVTGKRIQTTSLPFEHIQSPLEVASLDVNFVAIVFFIILTLASFSLIAASHAGNISHERSTRVKRLLYISGLRKSIYWLSNLIWDYLQTFILVIFLTIVIIAVDDKFRTHFDLYISGVVLFTFSIIPLSYLMSFKFSSHGKAVGAIFAIHFGVGLIFTVISFILRVWAIKENSISFQFLTDIIEYCFYAISPFFCFSKILAIVTKFPGVSRVDQSFIDYWSFHFGLLPNAILFLHCIVWITWILLIDYSSEIKGKFTISKLFSNSPIPDSNEDSDVSNERIIVKQLLDNNTNGGSGNVYPIIFNNLYKKFNSVGNYKSKIAVYNSTLAIPTGQTFGLLGLNGCGKSTTLGMISGEISPTGGKIKLNGYDLIKNRNDALTSIGYCFQFDALIGLLSAREQLELYCRIKGVDESKIKDTVNAFIQMMDLESISNSNTSGYSGGNKRKVSLSIACIGSPSILLLDEISCGVDACVKRFMWNVLMELKKNKAIILTTHSIAECQAVCDKLTIMKDGKLQALGSNQHIKDKFGSGYSIEVKFKKEYLENGVELFLQSFPSASLIDNQHALSASFELPNPPNNPIKLSSIFSNIEQSLKFILDDYSVSQTSIEQIFIKLTKNSITNIDN

Gene
ABCA4
Protein
ABC transporter A family member 4
Organism
Arabidopsis thaliana
Length
937 amino acids
Similarity
Belongs to the ABC transporter superfamily. ABCA family. CPR flippase (TC 3.A.1.211) subfamily.
Mass
105.483 kDa
Sequence
MANHVPASFLTRANALFRKNLTYQKRNIWSNVRLIVIPFYLCVLLVGIQVLFDTQVNNSADNRCGCRCIHKNGDGKCERKSCGLQYSSLTQASFCAFPNPPPLLPLLQIPRPETRLVDPARSSCRRTGSCPVTILVTGNNHTLGETLSRNLLSTSFAVNSSDHFLRNLAYNVLGTISEADYTNYLDPGIHSDLPIFQIRPYCTPTTNLSFSFRQPPITFHKEVRCVQGLNLWRNNSVEVNDEIFKGYRQGNHEEIINEVAAAYDLLDTDRNKFNVTIWYNSSYKGNFKVQDRRVKYVRVPRSVNMVSNAYLRFLRGPGTKMLFDFVKEMPKQESMLRVDIASVIGPIFLTWVIVLLFPVILNSLVYEKQQHLRIIMKMHGLGDGPYWMITYAYFLAISTLYIICLMIFGSAIGLKFFRFNDYSIQFIFYFLCINLQISIAFLVSSAFSKVETASVAAYLYVFGSGLLGGFLFQFMLEGLSFPRGWIFVMELYPGFSLYRGLYEFSQYALKRQLNGSDGMKWKYFSDSAMDEVFYIIIIEWFLALIAAYYMDRVSSSAKDPFLFLKNLIKKSPSPQRHSLQRLGSSVSVEMEKLDVVEERAKVEQLMLESSTSHAIVCDKLKKVYPGRDGNPPKMAVGGLSIAVPPGECFGMLGPNGAGKTSFINMMTGLVKPTSGTALVESLDICQDMDKVYTSMGVCPQHDLLWETLTGREHLLFYGRLKNLKGSDLNQAIEESLKSVNLSREGVADKPAGKYSGGMKRRLSVAISLIGSPKVVYMDEPSTGLDPASRRSLWTAIKGAKKHTAIILTTHSMEEAEFLCDRLGIFVDGRLQCVGNPKELKARYGGSYVLTMTTSSEHEKDVEMLIQDVSPNAKKIYHIAGTQKFEIPKDEVRIAELFQAVEKAKGNFRVFAWGLADTTLEDVFIKVARTAQASNVFS