Protein
5'-AMP-activated protein kinase catalytic subunit alpha-2
Organism
Caenorhabditis elegans
Function
Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals (PubMed:15574588). Role in motility and response to oxidative stress (PubMed:18408008, PubMed:24763318). Involved in the establishment of germline stem cell (GSC) quiescence during dauer development (PubMed:15574588, PubMed:20110331). Plays a role in axon regrowth after axotomy in PLM neurons (PubMed:24431434). Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress (PubMed:26439621). Plays a role in the regulation of flp-7 secretion from ASI neurons (PubMed:28128367). Keeps the CREB-regulated transcription coactivator 1 homolog crtc-1 inactive which in turn inhibits flp-7 secretion (PubMed:28128367). Following serotonin signaling, derepresses crtc-1 which stimulates flp-7 secretion and subsequent body fat loss (PubMed:28128367).
Similarity
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Sequence
MFSHQDRDRDRKEDGGGDGTEMKSKSRSQPSGLNRVKNLSRKLSAKSRKERKDRDSTDNSSKMSSPGGETSTKQQQELKAQIKIGHYILKETLGVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQVISTPSDIFMIMEHVSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDLKPENLLLDEQNNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDEHVPSLFRKIKSGVFPTPDFLERPIVNLLHHMLCVDPMKRATIKDVIAHEWFQKDLPNYLFPPINESEASIVDIEAVREVTEFQRYHVAEEEVTSALLGDDPHHHLSIAYNLIVDNKRIADETAKLSIEEFYQVTPNKGPGPVHRHPERIAASVSSKITPTLDNTEASGANRNKRAKWHLGIRSQSRPEDIMFEVFRAMKQLDMEWKVLNPYHVIVRRKPDAPAADPPKMSLQLYQVDQRSYLLDFKSLADEESGSASASSSRHASMSMPQKPAGIRGTRTSSMPQAMSMEASIEKMEVHDFSDMSCDVTPPPSPGGAKLSQTMQFFEICAALIGTLAR