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ZNRF1

Gene
ZNRF1
Protein
E3 ubiquitin-protein ligase ZNRF1
Organism
Bos taurus
Length
227 amino acids
Function
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes degeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (By similarity).
Mass
23.712 kDa
Sequence
MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRAGGGAMGLRSRSVSSVAGMGMDPSSAGGVSFGLYTPASRGAGDAERAPGSGGSASDSTYAHGNGYQETGGGHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNRSCPEHPAD

Gene
ZNRF1
Protein
E3 ubiquitin-protein ligase ZNRF1
Organism
Homo sapiens
Length
227 amino acids
Function
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
Mass
23.783 kDa
Sequence
MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMDPSTAGGVPFGLYTPASRGTGDSERAPGGGGSASDSTYAHGNGYQETGGGHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNRSCPEHPAD

Gene
Znrf1
Protein
E3 ubiquitin-protein ligase ZNRF1
Organism
Mus musculus
Length
227 amino acids
Function
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes Wallerian degeneration, a neurodegeneration disorder, by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons.
Mass
23.843 kDa
Sequence
MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMDPSTAGGVPFSLYTPASRGTGDSERAPGGGGSTSDSTYAHGNGYQETGGGHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNRSCPEHPAD

Gene
znrf1
Protein
E3 ubiquitin-protein ligase znrf1
Organism
Danio rerio
Length
215 amino acids
Function
E3 ubiquitin-protein ligase that plays a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity.
Mass
22.875 kDa
Sequence
MGGKQSTAGRPRGAFPGVSTDDSAVPPSAHFGHYRPGGTMGLRSRSVSSVAGMGIDHSATVPFGFYTPRGTDSDRAGGGSGSDPAHNGNGYQETGGGHHTDGMLYLGSRASLADTLPLHIAPRWFSAHSGFKCPVCSKSVASNEMEVHFIMCLSKPRLSYNDDVLSRDAGECVICLEELQQGDTIARLPCLCIYHKSCIDSWFEINRSCPEHPSD

Gene
znrf1
Protein
E3 ubiquitin-protein ligase ZNRF1
Organism
Xenopus laevis
Length
195 amino acids
Function
E3 ubiquitin-protein ligase that plays a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity.
Mass
20.732 kDa
Sequence
MGGKQSSASRSRAPFPGVSSDDSAVPPSSNFGHFRGGGAMGLRSRSVSSVSGLDPPAAALPFGLYRAGPDTERGGGSGSEDSRGGLYLGSRASLADTLHITPRWIGAHSGFRCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTRDAGECVICLEELSQGDTIARLPCLCIYHKSCIDSWFEVNRCCPEHPSD

Gene
znrf1
Protein
E3 ubiquitin-protein ligase ZNRF1
Organism
Xenopus tropicalis
Length
195 amino acids
Function
E3 ubiquitin-protein ligase that plays a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity.
Mass
20.817 kDa
Sequence
MGGKQSSASRSRAPFPGVSSDDSAVPPSSNFGHFRAGGAMGLRSRSVSSVSGLDPPAPGLPFGLYRAGPDTERGGSSGSEDSRGDLYLGSRASLADTLQIAPRWIGAHSGFRCPICSKSVAPDEMEMHFIMCLSKPRLSYNDDVLTRDAGECVICLEELSQGDTIARLPCLCIYHKSCIDSWFEVNRCCPEHPSD