ZNF516

Gene

ZNF516

Protein

Zinc finger protein 516

Organism

Homo sapiens

Length

1163 amino acids

Function

Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).

Similarity

Belongs to the krueppel C2H2-type zinc-finger protein family.

Mass

124.289 kDa

Sequence

MDRNREAEMELRRGPSPTRAGRGHEVDGDKATCHTCCICGKSFPFQSSLSQHMRKHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGHEPEAGEAPLGEMRASEGLDACASPTKSASACNRLLNGASQADGARVLNGASQADSGRVLLRSSKKGAEGSACAPGEAKAAVQCSFCKSQFERKKDLELHVHQAHKPFKCRLCSYATLREESLLSHIERDHITAQGPGSGEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHICGRRFKEPWFLKNHMKAHGPKTGSKNRPKSELDPIATINNVVQEEVIVAGLSLYEVCAKCGNLFTNLDSLNAHNAIHRRVEASRTRAPAEEGAEGPSDTKQFFLQCLNLRPSAAGDSCPGTQAGRRVAELDPVNSYQAWQLATRGKVAEPAEYLKYGAWDEALAGDVAFDKDRREYVLVSQEKRKREQDAPAAQGPPRKRASGPGDPAPAGHLDPRSAARPNRRAAATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRERDSDGDRAARARCGSLSEGDSASQPSSPGSACAAADSPGSGLADEAAEDSGEEGAPEPAPGGQPRRCCFSEEVTSTELSSGDQSHKMGDNASERDTGESKAGIAASVSILENSSRETSRRQEQHRFSMDLKMPAFHPKQEVPVPGDGVEFPSSTGAEGQTGHPAEKLSDLHNKEHSGGGKRALAPDLMPLDLSARSTRDDPSNKETASSLQAALVVHPCPYCSHKTYYPEVLWMHKRIWHRVSCNSVAPPWIQPNGYKSIRSNLVFLSRSGRTGPPPALGGKECQPLLLARFTRTQVPGGMPGSKSGSSPLGVVTKAASMPKNKESHSGGPCALWAPGPDGYRQTKPCHGQEPHGAATQGPLAKPRQEASSKPVPAPGGGGFSRSATPTPTVIARAGAQPSANSKPVEKFGVPPAGAGFAPTNKHSAPDSLKAKFSAQPQGPPPAKGEGGAPPLPPREPPSKAAQELRTLATCAAGSRGDAALQAQPGVAGAPPVLHSIKQEPVAEGHEKRLDILNIFKTYIPKDFATLYQGWGVSGPGLEHRGTLRTQARPGEFVCIECGKSFHQPGHLRAHMRAHSVVFESDGPRGSEVHTTSADAPKQGRDHSNTGTVQTVPLRKGT

Protein

Zinc finger protein 516: ZNF516

Gene

Znf516

Protein

Zinc finger protein 516

Organism

Mus musculus

Length

1157 amino acids

Function

Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress (By similarity).

Similarity

Belongs to the krueppel C2H2-type zinc-finger protein family.

Mass

124.788 kDa

Sequence

MDRSREAEMELRRGPSPPRAGRSHEVDGDKAACHSCCICGKSFPFQSSLSQHMRKHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGHEPEAGEAQLGEMRVSEGLDGCASPTKSTSACNRVLNGAVPMDGSKILLRSSRKEVEGAASAQEDTEATVPCSFCKSRFERKKDLELHVHQAHKPFKCRLCSYVTLREESLLSHIERDHITAQVPNGSEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHICGRRFKEPWFLKNHMKAHGPKAGSKNRPKSELDPIATINNVVQEEVIVAGLSLYEVCTKCGNLFTNLDSLNAHNAIHRKVEASRIRAPAEEGDSEDPLDTKQFFLQCLNLTPYVAGDVSPGGQAGRRVAELDPVNSYQAWQLATRGKVAEPAEYLKYGTWDEALAGDVAFDKDKREYILVSQEKRKREQDAPATQAPPRKRASVPGDPMLSGHLDPRPTSRPNRRASATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRDRDPEGDRAARARCGSLSEGDSASQPSSPGSACAIADSPGLAEEVVDDSGEEAVPEPASGGQPRHCCSSGEVTPTALSNGDQNHKLGNNLPEKDISEPKVGSAMPSVSILENSSRETTKGPEQHRYSLDLKMPAFHPKQEVPSTTDRVDFPASMEITSLQHTLDSQAGHSKEKLSDLHKEHCGVGKRASAPDLVPLDLSMRSSRDEPSGKEACSLQAALVIHPCPYCTHKTYYPEVLWMHKRIWHRVSCSSVAPPWTQPSGHKSIRSNLVFLTRSGRTGPPPALGGKECQPLLLSRFARTQVPGGAPGSKGSSSPLGVTTKAASMPKNKESHSGGPCALWASGPDGYRQTRAGHGQEPPSAAVQGPLAKPKQEGSSRLAPSPGSGSLSRSTTPTPSVITRVGAQPSANSKPVEKLGGPAVGTGFTPPNKHSAPDSLKAKFSPQPQGQPPLKGEGGSPLPPREPSVKAAQELRTLATCAAGSRGEAALQAPPGAPPTLNSAKQEPAAEGQEKRLDILSIFKTYIPKDFATLYQGWGVSSPGPEHRGTSLTGTPRTQAHQGDFVCVECGKSFHQPSQLRAHLRAHTVVFECDGPRDSEVHTASTDAPKQGRDHTTPGTVPAGPLRKGI

Protein

Zinc finger protein 516: Znf516