Protein
Zinc finger protein 24
Organism
Rattus norvegicus
Function
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro (By similarity).
Similarity
Belongs to the krueppel C2H2-type zinc-finger protein family.
Sequence
MSAQSVEEDSILIIPNPDEEEKILRVKLEEDPDGEEGSSISWNHLPDPEIFRQRFRQFGYQDSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVAILPRELQTLVREHHPENGEEAVTVLEDLESELDDPGQPVSLRRRKREVLVEEIASQEDAQGLPSSELDAVENQLKWASWELHSLRHCDDDATAENGALAPKQEIASAGESHEVPGTLNIGVPQIFKYGETCFPKGRFERKRNPSRKKQHICDECGKHFSQGSALILHQRIHSGEKPYGCVECGKAFSRSSILVQHQRVHTGEKPYKCLECGKAFSQNSGLINHQRIHTGEKPYECVQCGKSYSQSSNLFRHQRRHNAEKLLNVVKV