XRN2

5'-3' exoribonuclease 2

1012 amino acids

Possesses 5'->3' exoribonuclease activity (PubMed:11106401). Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA-derived loops, excised during miRNA maturation in the nucleus (PubMed:17993620). Involved in pre-rRNA processing. Involved in the primary exonucleolytic shortening of the 5' external transcribed spacer (5'ETS), required for endonucleolytic processing at site P by the U3 snoRNP complex. Involved with XRN3 in the 5'-end processing of 5.8S and 25S rRNAs. Contributes with XRN3 to polyadenylation-dependent nuclear RNA surveillance. Involved in the degradation of aberrant polyadenylated pre-rRNA through 5'-end processing (PubMed:20338880).

Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.

116.385 kDa

MGVPSFYRWLIQRYPLTIQEVIEEEPLEVNGGGVTIPIDSSKPNPNGYEYDNLYLDMNGIIHPCFHPEDKPSPTTFTEVFQCMFDYIDRLFVMVRPRKLLFMAIDGVAPRAKMNQQRARRFRAAKDAAEAAAEEEQLREEFEREGKKLPPKVDSQVFDSNVITPGTEFMATLSFALRYYIHVRLNSDPGWKNIKVILSDANVPGEGEHKIMSYIRCNKNHPGYNPNTHHCLYGLDADLIMLSLATHEIHFSILREVVFFPGEEGKCFLCGQEGHRAADCEGKIKRKTGEMLDNTEADVVVKKPYEFVNIWILREYLEHDMQIPGAKKNLDRLIDDFIFICFFVGNDFLPHMPTLEIREGAIELLMSVYKNKFRSAKKYLTDSSKLNLRNVERFIKAVGMYENQIFQKRAQVQQRQSERFRRDKARDKARDNARDNAQASRQFSGKLVQLDSLDEVSDSLHSSPSRKYLRLSLDDNIGVANVETENSLKAEELDNEEDLKFKLKKLLRDKGDGFRSGNGEQDKVKLNKVGWRERYYEEKFAAKSVEEMEQIRRDVVLKYTEGLCWIMHYYYHGVCSWNWFYPYHYAPFASDLKGLEKLDIKFELGSPFKPFNQLLAVLPSASAHALPECYRSLMTNPDSPIADFYPADFEIDMNGKRYSWQGISKLPFVEEKRLLEAAAQVEKSLTNEEIRRNSALFDMLFVVASHPLGELIRSLNSRTNNLSNEERATIIEKIDPGLSDGMNGYIASCGGDSQPSCFCSTVEGMEDVLTNQVICAIYKLPEDIRGSEITHQIPRLAIPKKTISLVDLKSGGLLWHEDGDKRRAPPKVIKIKRYNPEGSISGGRLGKASHRLVLQTINAQPDYMNINSEPALCPNTVFQNERVPKKIPTFKDNGIQWISPPPSQITPKKMNSPQRQKAWKKDETPQSREKSKKLKSSLKVNPLKMKKTKSPQREFTREKKKENITPQRKLTKAQRQVKHIRMMEEAKMIKQRKKEKYLRKKAKYAQGAPPKTA

Xrn2

5'-3' exoribonuclease 2

951 amino acids

Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity).

Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.

108.687 kDa

MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFNIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCALCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFPFDVERSIDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGCQVASNPRQAAYEMRMQRNSSPSISPNTSFASDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMSSEFEKGTKPFKPLEQLMGVFPAASGNFLPPTWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEENRRNSLGGDVLFVGKLHPLRDFILELYQTGSTEPVDVPPELCHGIQGTFSLDEEAILPDQTVCSPVPMLRDLTQNTAVSINFKDPQFAEDYVFKAAMLPGARKPATVLKPGDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVTPRGSGTSVYTNTALPPANYQGNNYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQHRFERSVGAEPLLPWNRMIQNQNAAFQPNQYQMLGGPGGYPPRRDDHRGGRQGYPREGRKYPLPPPSGRYSWN

XRN2

5'-3' exoribonuclease 2

950 amino acids

Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).

Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.

108.582 kDa

MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN

XRN2

5'-3' exoribonuclease 2

950 amino acids

Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity).

Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.

108.56 kDa

MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLLREKKVKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPIGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDADAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVDVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPATYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLSPPSGRYNWN

XRN2

5'-3' exoribonuclease 2

949 amino acids

Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II (By similarity).

Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.

108.542 kDa

MGVPAFFRWLSRKYPSIIVNCVEEKAKECNGVKASVDTSKPNPNEVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRIFNIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAEEKQKIRQEILAKGGILPPEEVKERFDSNCITPGTEFMDNLAKCLRYYIADRLNSDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPHFTIIREEFKPNKPKPCALCNQMGHEVKDCQGLPREKQGKHDQFADSLPASEQEFIFIRLCVLREYLERELTMASLPFTFDFERSVDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGGYLTESGFVNLQRVQMIMLAVGEVEDSIFKKRKDDDDNFKRRQKEKKKRMKRDHPSFIPGGQFSPQALGNRSSPQAISNPRQTAFEMRMHDRQNSTMSSPNTSLNSDGSPSPARGIKRKSEDSDSEPEPEDNIRLWESGWKQRYYKNKFDVDASDEKFRRKVVQSYVEGLCWVLRYYYQGCASWNWYYPFHYAPFASDFEGIADMPSDFEKGSKPFKPLEQLMGVFPAASGNFLPPTWRKLMTDPESSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEENRRNSLGGDVLFVGKHHPLCDFIVEQYKSKNTEPVDMPPELCYGIQGKLTPNENAVLPDKTVESPVPMLRDLTQNSAVSISFKDPQFDEDFIFKATVLPGAKKPPPVLKPGDWEKTNNDGRPWRPQLGFNRDRKPVHLDQSAFRTLGHAMPRERGMPGMYANAVPLGAYGSPYTRPLMSGQQQIPKLLSNLRPQESWRGPTPLFQQAPQRTAGAAPLLAWNRMLPAQSQYPPGQYQGLGGPMSYPQRPEDRMDRGRQAYGPGRPYLLPPPSGRYSWN