Protein
Inhibitor of apoptosis protein
Organism
African swine fever virus (isolate Warthog/Namibia/Wart80/1980)
Function
Prevent apoptosis of host cell by inhibiting caspase-3/CASP3 activation. Induces also the activation of host NF-kappaB.
Similarity
Belongs to the asfivirus IAP family.
Sequence
MFPKINTIDPYISLRLFEVKPKYVGYSSVDARNQSFAIHDIKNYEKFSNAGLFYTSPTEITCYCCGMKFCNWLYEKHPLQVHGFWSRNCGFMRATLGIIGLKKMIDSYNDYYNNEVFVKHKNRVYTHKKLEDMGFSKPFMQFILANAFIPPYRKYIHKIILNDRYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL