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WOSG25_110680

Gene
WOSG25_110680
Protein
Putative botulinum-like toxin Wo
Organism
Weissella oryzae (strain DSM 25784 / JCM 18191 / SG25)
Length
1336 amino acids
Function
When overexpressed the N-terminus (residues 1-476) cleaves rat synaptobrevin-2/VAMP2 between '89-Trp-|-Trp-90' in vitro. This releases the cytoplasmic domain of VAMP2 from the synaptic vesicle membrane, which would prevent the assembly of the trans-SNARE complex on the membrane and thus prevent vesicle-target membrane fusion and neurotransmitter release (PubMed:27443638).
Similarity
Belongs to the peptidase M27 family.
Mass
153.025 kDa
Sequence
MDVLEMFDVNYESPILESFDSTTQSLNDVHVFMSRIQMSAYDADGEGRIEYRNLKLYEISSGIFISTDRLDTGASGVEDDHEMVDYYSSARLTREFLGESLDSQKSDYFEGIKKVFSFYKNKCNESRYIKEFFEEIQFRNICGFPKQAGTSSTDIFDQFNSVDVLLQDPVTSVWNKKVGSKKANIVIIPPATNLPITEACATAGFQPEGFPKLGSGSFFTVQFDPFFSTRFKAHETDDVALLDPTLTLLHEMTHGLHFQKGIANPVNRSGETPAWATTWGRVTGDNDAFKETPMEELLTFNKHTIDDDIEISDHLKSTYIGFLYNGRNEDDPTESVDGVYQNVSSFLNQYRGFEISSDFQHFIESCYGVKYNQESKKFIVNPRNIKRYVQDGFFIDEAKFARILNIKTRSYYTLMPDNLGVWSYRVDILNRLRETFDEDRGLLSQELDFHTALTPVVSENPALELEVAGMQRMVSLPKIKASYLPSDIKIKNFTGQKISHDTILDTNISGIIISKIKYKSDFVVDESMPRSSLNTTNYNLSPIKGTKFETDIRDKTSVKVTVSEITAPMINHVMKLDNSKVLTERPSLNEDLEETFKNTKDVYIPKTTAMMKLKEGADQTLGAVGFAVWSGQILEDLYNLAQKKEVSIDQIKDDLMSILPFYCAYKNLSAEKYEQAFANATLDAFLIFATDGGGFAGLGITVGAIAINSMYAKAETMEAYDSMFGKYVDQYQNDIKNFTLNAYVQWENNILSRLWNESRLAITGFRNMLKTVKTVMEFDATNQAYSEEDRKIIKAKCEEIFSEFPMLMQTFAKNSMTANLENASKIFNDIVWQKIKEELDQYVIDSKKYFLDSLEEAYNNGSISAESYYKYQTEAREKFVSPREVIDLYIAAHDTVVKRKRYIRRYSRKYDLATDFKGNTVHLNGLGEGTQDIQDLYGNYSVYADKKTVSTQEGHFDQTIKIAKDTNTINKVVLAVSSNNGKEYALNKDEQYTISFWLRMPVPSSSEERRIFSYSAVSGVNKEVEELILQVKNNEFVLATANLLRNSEFVIEPRIALNRWVKITIVNENTRIKVYQNDNLLGLIKDSSRKKPIAQRGTFKFYNYNVDYQLDDISYYNGTISQRDIKYTFKEDHGQFVYDHWGERLQYNKAYYLLSDDNKSAFETVYETKRLKLKSVPGVDIKYLGMNDRVYGYYGGLQFKLVPLDSKNMNNYVRWGDKFTMQSIETTNLSLAIIQDNAYFAPTQLKLISNEGKSEEEIFTFDRNIKLQNAAILVGTGNSKQGPISAYKRGYSGDLWINGARLDGYVTVVNKSNYSNDEIQEKFKWIFVPKDANWVE