Function
Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.
Sequence
MSNSSIVPTYNGYIHNTRDALAVIQQVLDKQLEPVSRRPHERERGVLIVSGSVFVFIEQSSGIKRWTDGISWSPSRIQGRFLVYGELDKKNLIDKDKKKKKKRKFGPDDEYDHNVNEPDYTGGYGNHLHNDNRSHLNKNSRSGPMLLATGTGSITHTVIENKPSSSASMIHSNVIPASSSFLTDYRTSLGNGPMVSAAISQNGLVKKTITLTTTTKELHMEGKAEKQTIHLISYYSKQDIDSGKLQRPSESDLKHVQISPALWTMVQENSLGGKAPIDDEECFIVDGHNQYTNVSYIQQQQQQHQLQHQPLLHHSSSVAGSTTSIVNNSLSISNGGYGNNYSKNLSRSYNKYSNSQVSQLSYMLPPQTESSSTATIASGASVSVKREDDTNNGSNAPTGNENQYVNAINHSHTSSYGGQGYATDATGIATPAYNSYSQANTSINTSSQQQQQLQQGQYGQYVQYGVAPSTISGATSTNNNSGNAPNIPQDVYYSHYTGFVQPHYPQYHIATGNASDQYNTNAANHQYHSNNTTSSANNNSSSRTTGVGSKRKPSIVSNSTSGSVSGGNGNGNNYGYNSNSSTSTNRPPAVSTNTTSTTSGGSSFSGPSSNITTNSMSNNPWFNSSTNMAVNSSYITSSGGGNSHGGIGNNEYEPMPMTNNSASIPAYYQQHVPSHVGSAQQHQSQQQVAGVGAPHIIHNHPYLHPTYGQGSNSASTGDNSTPGGSSGSGSGGSGNNGAGGSSSVAATSGVTSSNTSGNIVTNGTLVAAGTDDAVGNSSGSYYTGT