Organism
Ambystoma mexicanum
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (By similarity).
Similarity
Belongs to the Wnt family.
Sequence
MRPMTFIVGLKTLWILAFSSLSNTLAVNNSGRWWGVVNVVTSTNLLTDTKNVQLVLDPSLQLLSRKQRKLIRQNPGILHSINSGLQSAMKECKWQFRSRRWNCPTTGGDNIFGKIVNKGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGTDWHWGGCSDNIDFGRVFGREFVDSSERGRDLRYLMNRHNNEAGRMTVFSEMKQECKCHGMSGSCAVRTCWMRLPTFRAVGDFLKDRFDGASRVIYGNKGSNRASRVQTHHLEPENPTHKPPSPQDLVYFEKSPNFCTYNGKTGTSGTSGRVCNSSSLGLDGCELLCCGRGYRTKTQRVTERCHCTFHWCCHVSCLNCTNTQVLHECL