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WIPI2

Gene
WIPI2
Protein
WD repeat domain phosphoinositide-interacting protein 2
Organism
Homo sapiens
Length
454 amino acids
Function
Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
Similarity
Belongs to the WD repeat SVP1 family.
Mass
49.408 kDa
Sequence
MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD

Gene
Wipi2
Protein
WD repeat domain phosphoinositide-interacting protein 2
Organism
Mus musculus
Length
445 amino acids
Function
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.
Similarity
Belongs to the WD repeat SVP1 family.
Mass
48.477 kDa
Sequence
MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSASIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLEAVREKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSASHDCPLATQTYGTAAAKGAYVPSSPTRLGKGQDANLEAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD

Gene
Wipi2
Protein
WD repeat domain phosphoinositide-interacting protein 2
Organism
Rattus norvegicus
Length
445 amino acids
Function
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.
Similarity
Belongs to the WD repeat SVP1 family.
Mass
48.519 kDa
Sequence
MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLEAVREKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSASHDCPLVTQTYGTAAAKGAYVPSSPTRLGKGQDANLEAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD

Gene
WIPI2
Protein
WD repeat domain phosphoinositide-interacting protein 2
Organism
Gallus gallus
Length
436 amino acids
Function
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures.
Similarity
Belongs to the WD repeat SVP1 family.
Mass
47.775 kDa
Sequence
MNLAGQSGDAGSGHLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPQEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICALATIQKIPRLLVGAADGYLYMYNLDPQEGGECTLMKQHKLDGSMEPANEILESASHDRPLVAQTYSAAVTKGTYVPSSPTRHAYTEDLGAVGGACLEDETNSLRLDEDSEHPPMILRTD

Gene
wipi2
Protein
WD repeat domain phosphoinositide-interacting protein 2
Organism
Xenopus laevis
Length
435 amino acids
Function
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures.
Similarity
Belongs to the WD repeat SVP1 family.
Mass
47.693 kDa
Sequence
MNLASQSVDAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTTLAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCSLSINGENCYLAYPGSASIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDSIFLSASSNTETVHIFKLETIKEKPPEEPTSWTGYFGRVIMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICALATIQKISRLLVGAADGYLYIYNFDPQEGGECTLMKQHKLDGSMEPSSEILESSSHDRQVGAQTYSATVTKTYPPPSPTRHAYADDLGAVGGASEEDEMGNLRLDEDNENPPMILQTE