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WDR82

Gene
Wdr82
Protein
WD repeat-containing protein 82
Organism
Drosophila melanogaster
Length
317 amino acids
Function
Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3.
Similarity
Belongs to the WD repeat SWD2 family.
Mass
35.355 kDa
Sequence
MKIKLIDSVVRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIHSSTKVDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPIAAYDPEGLIFAAGVNSESIKLYDLRSFDKGPFVTFKLNQEKECDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNNKGIPIEASFSPDSQFIFSGSTDGRVHIWNADTGNKVSVLNGDHPGPVQCVQFNPKYMMLASACTNMAFWLPTSEEGL

Gene
WDR82
Protein
WD repeat-containing protein 82
Organism
Gallus gallus
Length
313 amino acids
Function
Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus.
Similarity
Belongs to the WD repeat SWD2 family.
Mass
35.105 kDa
Sequence
MKLTDNVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHTKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGGFIRLIDAFKGAVLHTFGGYNNSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGMKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD

Gene
wdr82
Protein
WD repeat-containing protein 82
Organism
Danio rerio
Length
313 amino acids
Function
Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus.
Similarity
Belongs to the WD repeat SWD2 family.
Mass
35.001 kDa
Sequence
MKLTDSVLRSFRVAKVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKLQYERTCEWTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSKGVILEASFTPDSQFIMIGSEDGKIHVWNAESGMKVALLDGKHTGPVTCLQFNPKFMTFASACSNMAFWLPTIDD

Gene
WDR82
Protein
WD repeat-containing protein 82
Organism
Homo sapiens
Length
313 amino acids
Function
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
Similarity
Belongs to the WD repeat SWD2 family.
Mass
35.079 kDa
Sequence
MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD

Gene
Wdr82
Protein
WD repeat-containing protein 82
Organism
Mus musculus
Length
313 amino acids
Function
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Possible role in telomere length maintenance and in mRNA processing (By similarity).
Similarity
Belongs to the WD repeat SWD2 family.
Mass
35.079 kDa
Sequence
MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD

Gene
wdr82
Protein
WD repeat-containing protein 82
Organism
Xenopus tropicalis
Length
313 amino acids
Function
Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus.
Similarity
Belongs to the WD repeat SWD2 family.
Mass
35.204 kDa
Sequence
MKLTDNVLRSFRVAKVFRENSDKINCFDFSPTGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTALKFSNDGKLILMSTNGGFLRLVDAFKGAVMHTFGGYNNSKAVTLEATFTPDSQFIMIGSEDGKIHVWNCESGMKVAVLDGKHTGPITCLQFNPKFMTFTSACSNMAFWLPTIDD