WDR34

Gene

WDR34

Protein

WD repeat-containing protein 34

Organism

Homo sapiens

Length

536 amino acids

Function

Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.

Mass

57.801 kDa

Sequence

MATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRWETKSCQTASIATASASAQARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVIRELNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVACAYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLSTEFTEQGPREAEDLDCLAAEVAA

Protein

WD repeat-containing protein 34: WDR34

Gene

Wdr34

Protein

WD repeat-containing protein 34

Organism

Mus musculus

Length

535 amino acids

Function

Mass

57.971 kDa

Sequence

MCASPRPFRRVGSAGAAALAAGGAGGAERRGRPAPLQDETLGVASVPSQWRSVQGIRGETKSCQTAGIATAESSAQARTHADAQVQTEAPEEPAAMAPVSQYDTLRLEAFLRRVEAMVIRELNNNWQSHAFDGYEVNWTEQQQTVSCLHTLVYPLAQGQGLHVTGISWNSTGSVLACAYGRLDDGDWSTLKSYVCTWNLDRQGLNPQQPSVVVEVPSAVMCLAFHPTQPSHIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTDPVYQVLWLPEPRHSHRFQVLSAATDGKVLLWRGSGAGQLRLTKGFALAVQQLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLASEVAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAQPLTSLQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFNSQQTQLLAAGDAKGMVKVWQLSTAFTEQGPREVEDLDQLEAEITT

Protein

WD repeat-containing protein 34: Wdr34