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WDR1

Gene
WDR1
Protein
WD repeat-containing protein 1
Organism
Gallus gallus
Length
609 amino acids
Function
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity).
Similarity
Belongs to the WD repeat AIP1 family.
Mass
66.567 kDa
Sequence
MRMPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVVIRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDLAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTLSDHTRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGGGKAHDGGIYAISWSPDSSQLLSASGDKTAKIWDVGANSVVSTFNMGSNVLDQQLGCLWQKDHLLSLSLSGYINYLDKNNPDKPLRVIKGHSKSIQCLTVHKNGGKSYIYSGSNDGHINYWDSDTGENDGFSGKGHTNQVSRMAVDEMDQLVTCSMDDTVRYTNLSKRDYSGQDAVKMDVQPKCLAVGPGGYTVVLCIGQIVLMKDKKKCFAIDDLGYEPEAVAVHPGGGSVAVGGTDGNVRLYSIQGTSLKSDDKTLEAKGPVTDLAYSHDGAFLAVCDANKVVTVFSVPDGYVEHNVFYGHHAKVVCIAWSPDNEHFASGGMDMMVYVWTVSDPETRIKIPDAHRLHHVSGLAWLDEHTLVTTSHDASVKEWSISYN

Gene
wdr1
Protein
WD repeat-containing protein 1
Organism
Xenopus tropicalis
Length
607 amino acids
Function
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin (By similarity).
Similarity
Belongs to the WD repeat AIP1 family.
Mass
66.311 kDa
Sequence
MPYELKKVFASLPQVERGVAKIITGDPKGNNFLYTNGKSVIIRNIENPAIADIYTEHAHPVVVARYAPSGFYIASGDTSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGSVFLWDTGSSVGEISGNIKVINSVDIKQTRPYRLVTGSDDNCCAFFEGPPFKFKFTMADHSRFVNCVRFSPDGSRLASAGADGQIFLYDGKTGEKVGNLGGSKAHDGGIYAVSWSADSTQLLSASGDKTAKIWDVAANSAVTTFHLGTEVLDQQLGCLWQKDYLLSVSLSGYINYLDKNNPSRPLRVIKGHNKSIQCMTVHNSDGRSTIYTGSHDGHINYWDAETGENDTFTGKGHTNQVSRMDLDSSNQLITCSMDDTVRYTSLTSKDYSSSESVKMDVQPKCVAVGSGGYVVTLCIGQIVLLKDKKKVFAIDSLDYEPEAVAIHKGSGTVAVGGVDGNVHLYSIQGNSLKDEGKSLPVKGAVTDLAYSHDGAFLAVTDANKVVTVFNVADGYSEQNVYYGHHAKAVSVAWSPDNEHFASSGMDMMVYVWTLSDPDARIKIPDAHRLHHVSSLAWLDEHTLATVSHDACVKQWTVTFK

Gene
WDR1
Protein
WD repeat-containing protein 1
Organism
Bos taurus
Length
606 amino acids
Function
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).
Similarity
Belongs to the WD repeat AIP1 family.
Mass
66.258 kDa
Sequence
MPYEIKKVFASLPQVERGVSKIVGGDPKGNSFLYTNGKCVILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLVTGSDDNCAAFFEGPPFKFKFTISDHGRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVNTFTMGSNVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDEHGQLVSCSMDDTVRYTNLTLRDYSGQGVVKLDVQPKCLAVGPGGYTVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGETVAVGGADGNVRLYSILGTTLKDEGKLLEAKGPVTDLAFSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTIAY

Gene
WDR1
Protein
WD repeat-containing protein 1
Organism
Homo sapiens
Length
606 amino acids
Function
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).
Similarity
Belongs to the WD repeat AIP1 family.
Mass
66.194 kDa
Sequence
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

Gene
Wdr1
Protein
WD repeat-containing protein 1
Organism
Mus musculus
Length
606 amino acids
Function
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing (PubMed:25915128). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage (PubMed:24840128). Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding (PubMed:17515402). Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (PubMed:25915128). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).
Similarity
Belongs to the WD repeat AIP1 family.
Mass
66.407 kDa
Sequence
MPYEIKKVFASLPQVERGVSKILGGDPKGDHFLYTNGKCVILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDTGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGESKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGSNVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLTVHRNGGKSYIYSGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVNESEQLVSCSMDDTVRYTNLTLRDYSGQGVVKLDVQPKCVAVGPGGYTVVVCIGQIVLLKDQKKCFSIDNPGYEPEVVAVHPGGDTVAVGGTDGNVRVYSILASTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETKVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

Gene
Wdr1
Protein
WD repeat-containing protein 1
Organism
Rattus norvegicus
Length
606 amino acids
Function
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).
Similarity
Belongs to the WD repeat AIP1 family.
Mass
66.181 kDa
Sequence
MPYEIKKVFASLPQVERGVSKILGGDPKGDNFLYTNGKCVILRNIDNPAVADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHILKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDTGSSVGEITGHNKVINSVDIKQNRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGSNVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVDESGQLVSCSMDDTVRYTNLTLRDYSGQGVVKLDVQPKCVAVGPGGYTVVVCIGQIVLLKDQKKCFSIDNPGYEPEVVAVHPGGDTVAVGGSDGNVRVYSILGATLKDEGKLLEAKGPVTDLAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETKVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY