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VPS54

Gene
VPS54
Protein
Vacuolar protein sorting-associated protein 54, chloroplastic
Organism
Arabidopsis thaliana
Length
1034 amino acids
Function
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Probably involved in pollen tube elongation and other polar growth.
Similarity
Belongs to the VPS54 family.
Mass
113.865 kDa
Sequence
MDSHPSLMGRSITNSNRSSLDLGRPSSSSSSSPSPLTKSISDASSQSLSSILNNPHGGKSGVYGSDASWVGWWSSSTFVAPAEFAPVASTKLPGSELTRSDFHGYVSSISESHGRFEDIRKHTREESCGFDQESHVSGLAACLREVPSLYFKEDFALEDGATFRSACPFSSLNENLALQEKLSQYLDVVELHLVKEISVRSDSFFEAQGQLQDLNVKIVEGCSRIRELKETIRLLDRNLVDSARQIQELSSTRINMLELQRKLRLILYVNQALSALKLLVASADCAGALDITDDLQNLLAGDELTGLYCFRHLRDHVTSSIDSINSILTSEFMRISIHDTGEIDVLILSAANIRGSISSNGNTGEEVKLEEEDTSTLCDRLLPLVIGLLRTAKFPSILRMYRDTLTSEMKNAIKKAVADLLPILVARSLESDFSHGERSVDDGGGLSLASKLRTLSSEAFVNLLTAIFKIVQAHLVRASEVKKAIEWILCNIDGHYAADSVAAAIAVGAVAAETAQEIGFQGGSLVSSPLGKATSKAPPLQGKSSDASSLMNMSRNFRADVLRENTEAVFAACEVTHGRWAKLLGVRALLHPKLKLQEFMSIYDLTQEFITSTEKIGGRLGSSIRGTLQSQAKAFVDSQHESRMTKLKAVLDQETWDEIDVPEEFQSIISSLFASQRLISGKVDDADLNSYHSNRLPLNGSLTSGSGDQNSELRNEKSESSEGSVVSDAQVKPTVSPESLERSKAGVSSATNNQSNQKAHGKSNLFYQGVGYHMVNCGLILLKMLSEYIDMNNSLPALSSEIVLRVVEVLRFFNTRTCQLVLGAGAMQVSGLKSIKAKHLALASQVIDFTYTIIPETRRILFSKVPETRKPLLSVEIDKVAQDFRIHRDEIYTKLVQIMRERLLAHLHGLPKVVEGWNRPPDTNKQTKEFAWPLTREVGYLHRVLSETLHEADVQAIFRQVISIIHTQTSQTLTNLEISSTEAKKRLKLHVELILKCIRSLPSDNANQSDIPNWGQLDEFFAEHFREEEAGEAE

Gene
VPS54
Protein
Vacuolar protein sorting-associated protein 54
Organism
Homo sapiens
Length
977 amino acids
Function
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061).
Similarity
Belongs to the VPS54 family.
Mass
110.589 kDa
Sequence
MASSHSSSPVPQGSSSDVFFKIEVDPSKHIRPVPSLPDVCPKEPTGDSHSLYVAPSLVTDQHRWTVYHSKVNLPAALNDPRLAKRESDFFTKTWGLDFVDTEVIPSFYLPQISKEHFTVYQQEISQREKIHERCKNICPPKDTFERTLLHTHDKSRTDLEQVPKIFMKPDFALDDSLTFNSVLPWSHFNTAGGKGNRDAASSKLLQEKLSHYLDIVEVNIAHQISLRSEAFFHAMTSQHELQDYLRKTSQAVKMLRDKIAQIDKVMCEGSLHILRLALTRNNCVKVYNKLKLMATVHQTQPTVQVLLSTSEFVGALDLIATTQEVLQQELQGIHSFRHLGSQLCELEKLIDKMMIAEFSTYSHSDLNRPLEDDCQVLEEERLISLVFGLLKQRKLNFLEIYGEKMVITAKNIIKQCVINKVSQTEEIDTDVVVKLADQMRMLNFPQWFDLLKDIFSKFTIFLQRVKATLNIIHSVVLSVLDKNQRTRELEEISQQKNAAKDNSLDTEVAYLIHEGMFISDAFGEGELTPIAVDTTSQRNASPNSEPCSSDSVSEPECTTDSSSSKEHTSSSAIPGGVDIMVSEDMKLTDSELGKLANNIQELLYSASDICHDRAVKFLMSRAKDGFLEKLNSMEFITLSRLMETFILDTEQICGRKSTSLLGALQSQAIKFVNRFHEERKTKLSLLLDNERWKQADVPAEFQDLVDSLSDGKIALPEKKSGATEERKPAEVLIVEGQQYAVVGTVLLLIRIILEYCQCVDNIPSVTTDMLTRLSDLLKYFNSRSCQLVLGAGALQVVGLKTITTKNLALSSRCLQLIVHYIPVIRAHFEARLPPKQYSMLRHFDHITKDYHDHIAEISAKLVAIMDSLFDKLLSKYEVKAPVPSACFRNICKQMTKMHEAIFDLLPEEQTQMLFLRINASYKLHLKKQLSHLNVINDGGPQNGLVTADVAFYTGNLQALKGLKDLDLNMAEIWEQKR

Gene
Vps54
Protein
Vacuolar protein sorting-associated protein 54
Organism
Mus musculus
Length
977 amino acids
Function
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling.
Similarity
Belongs to the VPS54 family.
Mass
110.397 kDa
Sequence
MASSHSSSPVPQGSSSDVFFKKEVDPTKHIRPVQSLPDVCPKEPTGDSHTLCVAPSLVTDQHRWTVYHSKVNLPAALNDPTLAKRESDFFTKTWGLDFVDTEVIPSLYLPQISKENFIAYQQEISQREKIHERCKNICPPKDTFDRTLLHIHDKSRTDLEQVPKIFMKPDFALDDSLTFNSVLPWSHFNTAGGKGSRDAASSKLLQEKLSHYLDIVEVNIAHQISLRSEAFFHAMTSQHELQDYLKKTTQAVKMLRDKIAQIDKVMCEGSLQILRLALTRNNCVKVYNKLKLMATVHQTQPTVQVLLSTSEFVGALDLIATTQEVLQQELQGIHSFRHLGSQLCELEKLIDKMMIAEFSTYSHSDLNRPLEGECQVLEEERLVSLVFGLLKQRKLNFLEIYGEEMIITAKNIIKERVINKVSQIEEIDTDVVVKLADQMRMLNFPQWIDLLKDIFSKFTVFLQRVKATLNIIHSVVLSVLEKSQRTRELEEIPQQRSAGKDSSLDTDVAYLTHEGWFISDAFSEGEPASAAVDTTSQRNTSPHSEPCSSDSVSEPECTTDSSSSKEQTSACAPPGGIEIIVSEDMRLTDLELGKLASNIQELLCNASDVCHDRAVKFLMSRAKDGFLEKLNSTEFIALSRLMETFIVDTEQICGRKSTSLLGALQSQANKFVNRFHEERRTKLSLLLDNERWKQADVPAEFQDLVDSIADGKIALPEKKPVVTEERKPADVLVVEGHQYAVVGTVLLLIRIILEYCQCVDNIPSVTTDMLTRLTDLLKYFNSRSCQLVLGAGALQVVGLKTITTKNLALSSRCLQLIVHYIPVIRAHFEARLPPKQWSMLRHFDHITKDYHDHIAEISAKLVAIMDSLFDKLLSKYEVKAPVPSPCFRNICKQMTKMHEAIFDLLPEEQTQMLFLRINASYKLHLKKQLSHLNVINDGGPQNGLVTADVAFYTGNLQALKGLKDLDLNMAEIWEQKR

Gene
Vps54
Protein
Vacuolar protein sorting-associated protein 54
Organism
Rattus norvegicus
Length
965 amino acids
Function
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling.
Similarity
Belongs to the VPS54 family.
Mass
108.842 kDa
Sequence
MASSHSSSPVPQGSSSDVFFKKEVDPTKHVRPVQSLPDVCPKEPTVTDQHRWTVYHSKVNLPAALNDPTLAKRESDFFTKTWGLGFVDTEVIPSLYLPQISKEHFIAYQQEISQREKIHERCKNICPPKDTFDRTLLHIHDKSRTDLEQVPKIFMKPDFALDDSLTFNSVLPWSHFNTAGGKGNRDAASSKLLQEKLSHYLDIVEVNIAHQISLRSEAFFHAMTSQHELQDYLKKTSQAVKMLRDKIAQIDKVMCEGSLQILRLALTRNNCVKVSNKLKLMATVHQTQPTVQVLLSTSEFVGALDLIATTQEVLQQELQGVHSFRHLGSQLCELEKLIDKMMIAEFSTYSHSDLNRPLEGECQVLEEERLVSLVFGLLEQRKLNFLEIYGEETIITAKNIIKECVINKVAQVEEIDTDAVVKLADQMRMLNFPQWIDLLKDIFSKFTIFLQRVKATLNVIHSVVLSVLDKNQRTRELEEVSQQRSAGKDNSLDTEVAYLTHEGLFISDAFSEAEPASAAVDTTSQRNTSPHSEPCSSDSVSEPECTTDSSSSKEQTPASATLGGVDIIVSEDMRLTDLELGKLASNIQELLCNASDVCHDRAVKFLMSRAKDGFLEKLNSTEFIALSRLMETYIVDTEQICGRKSTSLLGALQSQANKFVNRFHEERRTKLSLLLDNERWKQADVPAEFQDLVDSIADGKIALPDKKPAATEDRKPADVLVVEGHQYAVVGTVLLLIRIILEYCQCVDNIPSVTTDMLTRLTDLLKYFNSRSCQLVLGAGALQVVGLKTITTKNLALSSRCLQLIVHYIPVIRAHFEARLPRKQWSLLRHFDHITKDYHDHIGEISSKLIAIMDSLFDKLLSRCEVEAPAPSPCFRNICKQMTKMHEAIFDLLPKEQTQMLILRINASYKFHLKKQLSHLNVINDGGPQSGFVTADVAFYTGNLQALKGLKDLDLNMAEIWEQKR

Gene
vps54
Protein
Vacuolar protein sorting-associated protein 54
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
949 amino acids
Function
Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. Seems also to be involved in protein transport from Golgi to the plasma membrane and is required for the integrity of the actin cytoskeleton (By similarity).
Similarity
Belongs to the VPS54 family.
Mass
107.951 kDa
Sequence
MERISSAPSISLGYPPTESSAHLAPSFSDSATSTLSFKSLLEDPVNPIRPVYTPTRTEITPVTLSPIPITPVREFQPYLHEISQEYARYSKQKRASLRRYLEKHGKLEGSMKESSINGSLLRRSSVSTILRPASESSYPNSNSETITYDIDDNVNPSSSLVDNFSISSVPSVFFQSDFNLDDPQIFDVVSEHIDITQTSDAPNSNRNLLLNNSMLQEKISWYLDTVELHLLQEIENASDSFPMIIDNLKQLKKETRDNVEETKHLLEKLTEVNVMCDRHMDAISSEELACHQLTQLKKVVQTLEDIYSEHKKVSEDVKDQRFLEAINGINSIVTQLKKKSTELNVDLLSLPSVKSLREEHKVLYHTVSQSVVQQFSKFLTSDMHKFSTILDSNELKDIYLSKNRLIPSVTKSLPSAMEFDADFLHEVDVCIDCLTLTDSLQAALTLYKTAVFEAFENLAQQYFTDGVEMRSVRKSSDLRRSLSAASLSSLSDSSRRSSSAANPFQSMSITEFAEMLTNIYFSSLECLRRIRSQIKVLIDILSKKDTKQYHLSVILNDLMATSSDVVTQQVTTINNLRFRVLDTYPPNNVIYLFSLHIIFHNELESLCGITQSSFIPTIMRQLLDWFKNFQRYSTQKLASSFERELWEAIPVEPSCQDLANRVFECSGNTPVEWTRLLSPEAEKEDENHRVHHVKVSEDCTATVSFGKQSLHIVRSSVTLLETLDDYGKLLAHFSRLAPEFQTGMLDMFRTLNSRVYQLILGAGTVRSSGLSKVLGKHIALASQTIALFQLSLNSMCRYLSRVTGTRLTNETNKLDQDFTVHHLQIHDKFVSLMRERVAISCSQIASLSWDIDSPHGYIIDLSKSLIKLYKVLHRYSQRDCVEVIPDVIRMFEDRLQLELTDIARNPSKWPGVRIDLSYFYDMMASKCGYAGDRTLLEKFERTPEQQEAA

Gene
VPS54
Protein
Vacuolar protein sorting-associated protein 54
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
889 amino acids
Function
Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. Seems also to be involved in protein transport from Golgi to the plasma membrane and is required for the integrity of the actin cytoskeleton.
Similarity
Belongs to the VPS54 family.
Mass
101.52 kDa
Sequence
MSISETPHNKSQGLQKAAGRPKIVVPEGSPSRNSDSGSFTIEGDTSLNDDLLSISGSVTPRARRSSRLSLDSITPRRSFDSRTLSVANSRSFGFENETHSGSMDFSPLGNNSIYEIVMNTRRKNWLNYPTVADIPQVSLSKNDLDDHWKTHVIEYVKNIKSDYQIFQSTNNIRNMNQMEQLKELREGENMHEESFEANLRQGDAELINSIPDFYFSDKFQLDNPRTFHKVLDAIDLFLTKLDMKRQAERDEAFSELRDRLNDFLDIVETLLVTEISKSSHKFFHALSEVDNIQKRALDTMSELKELAQNIKTIDAENIRKKISHLEMIFKRKNVEKLEQGLLQAKLVLNKTDECKSMYEENKLDNCLELIKSIDYLIKGDDSINEDVQSWTRCWPYKLSNLRTIPALSATREFLTNMKIEIGGKFSLQLSILLIDDLRSFCKSIKPKETLHRIQTGSNDKKQTIFTDNFSSKITELIVRLNRCEELTSAFDLYREKSITELKSIIKIYLPTENAHADNNHDEKHLNNGSTSGSKLSRLIKEQTPAEFQSMLVNIFTHALEALRRLYGHQKLLLDISLNELASVKSPNENQHNMITQLDIRTGINEIIRIIQLRTGKIIAVRRELNLSLRYDYFLKFYAICVIFIQECEVLSGEFLTKYLSNVLASQIKHYANAQSSKNYRNIKKKIDAEEWIPYIVDSSIQSDVNDIVSSIDIDPLSWTTILDMVGGSHDCENGRSEDKEKDEGNETYQGHRKSVVVGDKTFVASSSLLATIEVIKELMVLSINLPSIYLSNFEKLCYDALQYYNSSAMASVTQPGNSLLKTGRNLSIMGESLDCLAEFVIIVQRFYQRLSNSNRDFEPFDASHYTTLLGQFQASSNKIYMANAPPPPV