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VPS4

Gene
vps4
Protein
Vacuolar protein sorting-associated protein 4
Organism
Dictyostelium discoideum
Length
444 amino acids
Function
Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex (By similarity).
Similarity
Belongs to the AAA ATPase family.
Mass
49.605 kDa
Sequence
MGDVNFLQKAIQIVQQATEQDNAKNYAEAHRLYIQSLEWFTTALKYEKSERSKATIKAKTLEYLQRAEQLKEYLDKSKNKKPVAVGGNKSNSAGSANGAGKSAKEDDEDMDPEDKKRNDSLSSSIVTTKPNVKWDDVAGLYQAKEYLKEAVIFPIKFPQMFTGNRKPWKGILLYGPPGTGKSYLAKAVATEISSTFFSISPSDIVTKWLGDSEKLVKQLFEMAREKNNSVIFIDEVDSLCSSRNDQESESARRIKTEFLIQMNGVGNDSDGILVLAATNIPWGLDLAIRRRFEKRIYIGLPEPQARAKMFQIHIGSTPNTLVQADYKKLADLTEGYSGSDIGSLVKDAIMQPVRAVQCATHFKQIRAPSREDPSVMTDYVTPCSPGDPLAQEMTWMDIDPTKLKEPEITIADCLKSLRVIKPSVNKADLDRYVEFTNDFGQDGV

Gene
VPS4
Protein
Vacuolar protein sorting-associated protein 4
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
439 amino acids
Function
Pre-vacuolar protein sorting protein involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. Required for extracellular secretion of the secreted aspartyl proteases SAP2, SAP4, SAP5, and SAP6. Its regulation of the pre-vacuolar secretory pathway is critical for virulence.
Similarity
Belongs to the AAA ATPase family.
Mass
48.437 kDa
Sequence
MSGASDFLSKGIDLVQKAIDADTATRYEEAYKLYYNGLDYLMLAIKYEKNPKSKELVKSKFTEYLTRAEQLKDHLEKQAQNKSTAESSVNGSTKAKKSNGDGNGSGDDNDDADTKKLRGALAGAILSEKPNVKWSDIAGLDAAKEALKEAVILPVKFPQLFVGNRKPTSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFTMARENKPSIIFIDEVDALCGPRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDAAVRRRFERRIYIALPDVEARTRMFEINIGDVPCECTPHDYRTLAEMTDGYSGHDVAVVVRDALMQPIRKIQQATHFKPVIDETDGKEKLTPCSPGDEGAREMNWMDLATDELKEPPLTIKDFIKAIKNNRPTVNEADIAQHVKFTEDFGQEGN

Gene
VPS4
Protein
Vacuolar protein sorting-associated protein 4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
437 amino acids
Function
Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex.
Similarity
Belongs to the AAA ATPase family.
Mass
48.172 kDa
Sequence
MSTGDFLTKGIELVQKAIDLDTATQYEEAYTAYYNGLDYLMLALKYEKNPKSKDLIRAKFTEYLNRAEQLKKHLESEEANAAKKSPSAGSGSNGGNKKISQEEGEDNGGEDNKKLRGALSSAILSEKPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNRKPTSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESEKLVKQLFAMARENKPSIIFIDEVDALTGTRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSAIRRRFERRIYIPLPDLAARTTMFEINVGDTPCVLTKEDYRTLGAMTEGYSGSDIAVVVKDALMQPIRKIQSATHFKDVSTEDDETRKLTPCSPGDDGAIEMSWTDIEADELKEPDLTIKDFLKAIKSTRPTVNEDDLLKQEQFTRDFGQEGN

Gene
vps4
Protein
Suppressor protein of bem1/bed5 double mutants
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
432 amino acids
Function
Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Involved in multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex (By similarity).
Similarity
Belongs to the AAA ATPase family.
Mass
48.402 kDa
Sequence
MSNPDCLSKAISLVKTAIDNDNAEQYPDAYKYYQSALDYFMMALKYEKNEKSKEIIRSKVIEYLDRAEKLKVYLQEKNNQISSKSRVSNGNVEGSNSPTANEALDSDAKKLRSALTSAILVEKPNVRWDDIAGLENAKEALKETVLLPIKLPQLFSHGRKPWSGILLYGPPGTGKSYLAKAVATEAGSTFFSISSSDLVSKWMGESERLVRQLFEMAREQKPSIIFIDEIDSLCGSRSEGESESSRRIKTEFLVQMNGVGKDESGVLVLGATNIPWTLDSAIRRRFEKRIYIPLPNAHARARMFELNVGKIPSELTSQDFKELAKMTDGYSGSDISIVVRDAIMEPVRRIHTATHFKEVYDNKSNRTLVTPCSPGDPDAFESSWLEVNPEDIMEPKLTVRDFYSAVRKVKPTLNAGDIEKHTQFTKDFGAEG