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VPS15

Gene
vps15
Protein
Probable serine/threonine-protein kinase vps15
Organism
Dictyostelium discoideum
Length
1966 amino acids
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
216.97 kDa
Sequence
MGNTVGAPIVSEYLEDEIGPIVFKKSLGNARFLKTVKAYHSEEGYVVVKIYKKRNTKESLEKYKIMLKEIKDNFNITPSFNIMPYQHFIETDRSGYLIRQYFHNNLYDRLSTRPFLSMIEKKFIAFQLLKALEQSSFKGVFHGDIKSENVLVTTSNWVYLSDFACYKPTFIPEDNPADFSFYFDTSGRRTCYIAPERFYETNRGAPSNNELTPKMDIFSLGCVIAELFLDGFPIFDFSQLLSYRKGEYSPEPIIRQRIQDPNIQTLILHMIQKDPDQRYTPEKYISKWNTVFPQYFSFAHQFIPELMRLENDDRVMCISDKFDEIVDIFKNNSITNLFKSNLNQSTNSNTIGSFRVSTPSSPILISNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQTTTTTTNTNINTTQQQQQQQQQQQQQLQRPLSKLDDIGKNIANIIYKTEQFVKESDEFDKTDITNIKELNIQTTPTINTSTINRVIQTSKTNTNLDTINENSNNNIGVNRKKVTVVEGLDLFLSVIYTAVKHCQFPSTKVKCVGSLLVRLAEMLDDECRLQKIVPYIMSMISPEQPTLVRVEALRSLAKVLEMVQTFPPSESSIFGQYILPSLSQLSHESTDEIIRIAFAEILPQLATTAKRFLEIAQHYRDPDSEGIMESRKDRAKFRVYDSDLQEVQDQFFNKVSDLLTKDSCNTLKKIILSDIYRLCVFFGRQKTNESVLPLIITFLNDRDWQLRCAFFENIVAVCTVVGAGSLESFIYPCILLALTDEEEFVTEKALSSLSELCSLGLLRKPILLELLVKTSPMLLHPNNWIRYGVVSLIVKICQSLSKADVYCYVKPKLSPFLVNLNGNGNGNAEISDTITESNLIQLLDSPISRESFNKIVKFIARNRINLSSSINSILANDNDNFNGESFNSNGSGGGGNPNLVSSTGGSNRRLRALSNKFFVPNILSASNSSINSTSGDIGSLLSQSTEESLAFLRQMTSIGISDSDQNKIIKCFDYLQSKKCKDLESANNSEGNVIVIRTNGTTIISSSNNSNNNTLSSSTTSSNSTTPTNSTVNLHSVLNNTTIIQQQQQQLQQTITQQSITQQQQQQQQQQQVSGGITTGGTTTTTLGRSSSPQLTGLNPSILSNSNNIQLSSSVVDVTKLPNSIPIRMVKIRGGDQSLNNSTVSLGSVAGGNIITPSTSLSNSNTMVGNNNNNSYNTSTSSSPLSSSVLNSSVGMNNLTNSNANSINNSSGINNNNSNNNSVNSNNYNNMNNNTMNNSVNLMNSNQIGQQQQQNPNTVKIDLVSPSDLNVVSKKYYIRDPKMGLSTILKVETNVECSIKVPLPLPDLGSTDSVLGGGLLSSGGVGGGVGGTGGGNINGVSGINGNVGGGGGGVGVGTVGSGGNGSIGGGNSGINNGSGGGGVNSGGNSGINSGSTNSSGSLYGNGNGLDNLPNSTWRPMGILVSHFFEHKAAVNEIQVSSDNLFFATASNDGTVKIWDCQRMEKSVTNRARQTYAQQEGRITSISICEKTHSIASASDKGSIHVFRVGISGKQKNGNIKYTNLSTVKNITETTRGNIVSVSHYSTNSSSVVTYATTKGGIHGWDLRSQQDAFNLVNDASLGLIQAFLIDPNRNWLVTGTSRGFLTCWDLRFGIPLYSVRVSNGRILKFAPYMLAKSASESWVYISTEQDNVIVFDLSNKKTTRVFKRSYEQPPQQQPQQPQPPQQQQQQQSQMNRSINMTSSTTTTTTSSYDFGTENLKTSSYSQLPSNPLVNSIVNNSNINNNNNNNDNSNNVTIFKPTPLVRALLNPPNCPFLITAGDDKRIKLWDWNNLPQSYYVSIGKEPPPFYTHKFSNDTSNAYEIHEEVWHDTSSSSFYSNSAMFGGGGGGQPMSTSLSSSSLSQQQHQAQLQLQYQLQQQQQQQQYINHLQQQKSKTSISMPTVHHQEPILDIKMMEVPNPMLISASTDGVVKVWK

Gene
VPS15
Protein
Serine/threonine-protein kinase VPS15
Organism
Arabidopsis thaliana
Length
1494 amino acids
Function
Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I (By similarity). Required for pollen development and germination, probably via the modulation of phosphatidylinositol 3-phosphate (PI3P) formation and vacuolar organization (PubMed:21833541, PubMed:22361507).
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
168.124 kDa
Sequence
MGNKIARTTQVSATEYYLHDLPSSYNLVLKEVLGRGRFLKSIQCKHDEGLVVVKVYFKRGDSIDLREYERRLVKIKDVFLSLEHPHVWPFQFWQETDKAAYLVRQYFYSNLHDRLSTRPFLSLVEKKWLAFQLLLAVKQCHEKDICHGDIKCENVLLTSWNWLYLADFASFKPTYIPYDDPSDFSFFFDTRGQRLCYLAPERFYEHGGETQVAQDAPLKPSMDIFAVGCVIAELFLEGQPLFELAQLLAYRRGQHDPSQHLEKIPDPGIRKMILHMIQLEPEARLSAEDYLQNYVGVVFPNYFSPFLHTLYCCWNPLPSDMRVATCQGIFQEILKKMMENKSGDEIGVDSPVTSNPMNASTVQETFANHKLNSSKDLIRNTVNSKDEIFYSISDALKKNRHPFLKKITMDDLGTLMSLYDSRSDTYGTPFLPVEGNMRCEGMVLIASMLCSCIRNIKLPHLRREAILLLRSCSLYIDDDDRLQRVLPYVVALLSDPTAIVRCAAMETLCDILPLVRDFPPSDAKIFPEYIFPMLSMLPEDTEESVRICYASNIAKLALTAYGFLIHSFQLSDVGVLNELNSQQISTTPASETPSHLQKANGNAQLQQLRKTIAEVVQELVMGPKQTPNVRRALLQDIGELCFFFGQRQSNDFLLPILPAFLNDRDEQLRSVFFEKIVYVCFFVGQRSVEEYLLPYIDQALSDQTEAVIVNALECLSTLCKSSFLRKRALLQMIECVYPLLCYPSQWVRRAVVTFIAASSECLGAVDSYAFIAPVIRSYLSRLPASIASEEGLLSCLKPPVTREVVYRIFEKTRNPEFMAKQRKMWYSSSPQSKDWESVDLFDKDAGELNSVECRAEQKQSVEGKKQIKSASKQPEVQGKYAEKDAKLRIPRNPRPNASNTVELRDPVYPEKLQFSGFMAPYVSGANSFIEPENIPLYSFSMDKRAATNPPVASESSLQMNSLGMGSLSVPWMDSMSKSFNLASSVPVPKLISGSFHVGTNPKQFYRVVHEPESRENDQISSAISKFQDLGVSSSSKSASVTSEDASSPADLVGEPSLSRTSVPDSGWKPRGVLVAHLQEHRSAVNDIATSSDHSFFVSASDDSTVKVWDSRKLEKDISFRSRLTYHLEGSRGMCTTMLRNSTQVVVGASDGVIHMFSIDHISRGLGNVVEKYSGIVDIKKKDVKEGALVSLLNYTADSLSGPMVMYSTQNCGIHLWDTRSDLDAWTLKANPEEGYVSSLVTSPCGNWFVSGSSRGVLTLWDLRFRVPVNSWQYPIICPIEKMCLCFLPPSVSVSTTMKPLIYVAAGCNEVSLWNAEGGSCHQVLRVANYENETDVSEFQWKLPSNKVNPKPNHRQNMSSKYRIEELNEPPPRLPGIRSLLPLPGGDLLTGGTDLKIRRWDYSSPERSYCICGPSLKGVGNDDFYELKTNTGVQFVQETKRRPLATKLTAKAVLAAAATDTAGCHRDSVQSLASVKLNQRLLISSSRDGAIKVWK

Gene
VPS15
Protein
Serine/threonine-protein kinase VPS15
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
1454 amino acids
Function
Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
166.372 kDa
Sequence
MGAQLSLVVQASPSIAIFSYIDVLEEVHYVSQLNSSRFLKTCKALDPNGEIVIKVFIKPKDQYSLRPFLQRIRAQSFKLGQLPHVLNYSKLIETNRAGYMIRQHLKNNLYDRLSLRPYLQDIELKFIAFQLLNALKDIHNLNIVHGDIKTENILVTSWNWCILTDFAAFIKPVYLPEDNPGEFLFYFDTSKRRTCYLAPERFNSKLYQDGKSNNGRLTKEMDIFSLGCVIAEIFAEGRPIFNLSQLFKYKSNSYDVNREFLMEEMNSTDLRNLVLDMIQLDPSKRLSCDELLNKYRGIFFPDYFYTFIYDYFRNLVTMTTSTPISDNTCTNSTLEDNVKLLDETTEKIYRDFSQICHCLDFPLIKDGGEIGSDPPILESYKIEIEISRFLNTNLYFPQNYHLVLQQFTKVSEKIKSVKEECALLFISYLSHSIRSIVSTATKLKNLELLAVFAQFVSDENKIDRVVPYFVCCFEDSDQDVQALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSDLAIIINRFQEFTFAQHCNDNSMDNNTEIMESSTKYSAKLIQSVEDLTVSFLTDNDTYVKMALLQNILPLCKFFGRERTNDIILSHLITYLNDKDPALRVSLIQTISGISILLGTVTLEQYILPLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYIDISKTTSPLLLHPNNWIRQFTLMIIIEIINKLSKAEVYCILYPIIRPFFEFDVEFNFKSMISCCKQPVSRSVYNLLCSWSVRASKSLFWKKIITNHVDSFGNNRIEFITKNYSSKNYGFNKRDTKSSSSLKGIKTSSTVYSHDNKEIPLTAEDRNWIDKFHIIGLTEKDIWKIVALRGYVIRTARVMAANPDFPYNNSNYRPLVQNSPPNLNLTNIMPRNIFFDVEFAEESTSEGQDSNLENQQIYKYDESEKDSNKLNINGSKQLSTVMDINGSLIFKNKSIATTTSNLKNVFVQLEPTSYHMHSPNHGLKDNANVKPERKVVVSNSYEGDVESIEKFLSTFKILPPLRDYKEFGPIQEIVRSPNMGNLRGKLIATLMENEPNSITSSAVSPGETPYLITGSDQGVIKIWNLKEIIVGEVYSSSLTYDCSSTVTQITMIPNFDAFAVSSKDGQIIVLKVNHYQQESEVKFLNCECIRKINLKNFGKNEYAVRMRAFVNEEKSLLVALTNLSRVIIFDIRTLERLQIIENSPRHGAVSSICIDEECCVLILGTTRGIIDIWDIRFNVLIRSWSFGDHAPITHVEVCQFYGKNSVIVVGGSSKTFLTIWNFVKGHCQYAFINSDEQPSMEHFLPIEKGLEELNFCGIRSLNALSTISVSNDKILLTDEATSSIVMFSLNELSSSKAVISPSRFSDVFIPTQVTANLTMLLRKMKRTSTHSVDDSLYHHDIINSISTCEVDETPLLVACDNSGLIGIFQ

Gene
VPS15
Protein
Putative serine/threonine-protein kinase VPS15
Organism
Komagataella pastoris
Length
1340 amino acids
Function
Involved in glucose-induced micropexophagy and ethanol-induced macropexophagy. Required for ATG2 recruitment to a perivacuolar compartment.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
151.917 kDa
Sequence
MGAELSLLAPTAQPIALSVYVDFLSNIQYNKPLGTSRFLKTVKGLNDQGSIVVKVLVKPNSGLDLSEWVEKLEFLRLKLLDVPNVIPYNLVIDSVRAGYLIRPFQQRTLYERVSIQPYLEPIEKKWIAFQLIHAVMECHERGQYHGDIKSENVLLTSWDMVFLTDFAPFKPIYLPGNNPSQFSFYFDTSRRNVCYVAPERFLGEGTPTQYQEVDKLTSSMDIFSLGCTVAELFLEGSVLFTLPQLFKYKKGEYTPSLSGIVDNDLRNMIQEMIDLDPRKRISAHDCLRKHRGKVFPEYFYSFLYDYMLELSTPSDHSVGNWRFDECDRRIERIYNDMGMICDKLDVNLDLNIVHSFTEEPSQNVIPMTLRLPGVEPHIPQSSKTPYDSALIILNILLHSMRNTTHSSYRIKSCDLILMISEMLSDEQKLDRCLPYLVHLLNDPSIDVQAAALKYMTQLLLLVDYLTPVNVLIFPEYILPKLASFLSTTKGSYMRMIFATILPHLAKTALKFYEMAILLGSHVEKFELLKNFENLTIQLLIDPDSSAKISLLKNILPLASVFGKDKTNDIILSHMITYLNDPDENLRVAFIESILGLSIFVGITSLENYILPLLVQTLTDNSEIVVVNVLRSFAELNNLGLIKKRYKFDLIKVSSKLLLHPNSWIRLGTLRLLISVVKDLSLTDFYCLLYPLVRPFFEYEVTNFDWATLYPCIIKPIPRSIYTLSITWALKAEKTLFWQQVKLAKPDPFGSRNSTFLLNRNSKIGESGVVSNNQIPTSPEDIGWLGKLKASGFDEKDLWKIATLRDYIFRVARSRSNIPTQENNEVTMQQMGIYPRIVFFEKGSMYETEGFVTGSSMMANYRILVNSEYSPESLTKRKTVGGVNTNHTYSGANPYILKFLECIKFRHVLDDSEEFGPSIPSATVEEGHWKFEGVLVSHLTEHTGSITSLALSPDQQYFLTGDSKGIIRLWDVLQLERNGYATSHVTVSMSSSVKDIKFIENRNSFCAVTADGEIKIFRVEINSTSSSVRSNGSPHRHESISLLREHSLEGEHISDMKFIGPNLAVTTLSCKLILFDLRDMQIAEEIQNPVSHGFITSFDLDSSQSWLLIGTSKGILDFYDLRFELLVKSWKLKSTSYPIKHITVPPAGFTCNRKSERFALINGGTNDSVTIVFDVSKGQCSELYFTETVNLNTAIDNYEVLEVDNGEERTRTSVLATEVEDRSITSLTMLGSNQFLTATFDKRVILWDTGNKANSSALISKLDDFTSSFSSVQVRPHLMAINEKIVEKDPQDIGGPKRNMASANSSTFDLHSDIITGIAVIQKPLKMLILVDRAGVINIYK