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VP2

Gene
VP2
Protein
Minor capsid protein VP2
Organism
Squirrel monkey polyomavirus
Length
332 amino acids
Function
Isoform VP3: structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2 or Vp3 nuclear localization signal (shared C-terminus). Isoform VP3 plays a role in virion assembly within the nucleus (By similarity).
Similarity
Belongs to the polyomaviruses capsid protein VP2 family.
Mass
36.559 kDa
Sequence
MGALLAVLAEVVELASVTGLSVESFISGEAFATAELLEAHIANLVTVGGLTEAEALAATEVPAEAYAALTSLSSTFPQAFTAVAATELATTGTLTVGATVAAALYPYYYDYSTPVANLNRGLNPEMALQLWFPEIDYEFPGLMPFVRFINYIDPTQWATNLFETIGRYSWESAQRYGQNLIAHEVRSASRELATRTAQGFSEAVARYFENARWAVSTLPRSLYSGLQSYYEQLPSLNPMQVRDLHRRLGQPIPNRIALEEQAIKSAEYVQKVDPPGGANQRIAPDWLLPLILGLYGDISPSWESTLEDIEEEEDAPQKKKRKRTKKNTPRSA

Gene
VP2
Protein
Dual specificity protein phosphatase VP2
Organism
Chicken anemia virus (isolate USA 26p4)
Length
216 amino acids
Function
May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication (By similarity).
Similarity
Belongs to the gyrovirus protein VP2 family.
Mass
24.067 kDa
Sequence
MHGNGGQPAAGGSESALSREGQPGPSGAAQGQVISNERSPRRYSTRTINGVQATNKFTAVGNPSLQRDPDWYRWNYNHSIAVWLRECSRSHAKICNCGQFRKHWFQECAGLEDRSTQASLEEAILRPLRVQGKRAKRKLDYHYSQPTPNRKKVYKTVRWQDELADREADFTPSEEDGGTTSSDFDGDINFDIGGDSGIVDELLGRPFTTPAPVRIV

Gene
VP2
Protein
Dual specificity protein phosphatase VP2
Organism
Chicken anemia virus (isolate Japan 82-2)
Length
216 amino acids
Function
May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication (By similarity).
Similarity
Belongs to the gyrovirus protein VP2 family.
Mass
24.139 kDa
Sequence
MHGNGGQPAAGGSESALSREGQPGPSGAAQGQVISNERSPRRYSTRTINGVQATNKFTAVGNPSLQRDPDWYRWNYNHSIAVWLRECSRSHAKICNCGQFRKHWFQECAGLEDRSTQASLEEAILRPLRVQGKRAKRKLDYHYSQPTPNRKKVYKTVRWKDELADREADFTPSEEDGGTTSSDFDEDINFDIGGDSGIVDELLGRPFTTPAPVRIV

Gene
VP2
Protein
Dual specificity protein phosphatase VP2
Organism
Chicken anemia virus (isolate Germany Cuxhaven-1)
Length
216 amino acids
Function
May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.
Similarity
Belongs to the gyrovirus protein VP2 family.
Mass
24.139 kDa
Sequence
MHGNGGQPAAGGSESALSREGQPGPSGAAQGQVISNERSPRRYSTRTINGVQATNKFTAVGNPSLQRDPDWYRWNYNHSIAVWLRECSRSHAKICNCGQFRKHWFQECAGLEDRSTQASLEEAILRPLRVQGKRAKRKLDYHYSQPTPNRKKVYKTVRWQDELADREADFTPSEEDGGTTSSDFDEDINFDIGGDSGIVDELLGRPFTTPAPVRIV

Gene
VP2
Protein
Dual specificity protein phosphatase VP2
Organism
Chicken anemia virus (isolate Australia/CAU269-7/2000)
Length
216 amino acids
Function
May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.
Similarity
Belongs to the gyrovirus protein VP2 family.
Mass
24.112 kDa
Sequence
MHGNGGQPAAGGSESALSREGQPGPSGAAQGQVISNERSPRRYSTRTINGVQATNKFTAVGNPSLQRDPDWYRWNYSHSIAVWLRECSRSHAKICNCGQFRKHWFQECAGLEDRSTQASLEEAILRPLRVQGKRAKRKLDYHYSQPTPNRKKVYKTVRWQDELADREADFTPSEEDGGTTSSDFDEDINFDIGGDSGIVDELLGRPFTTPAPVRIV

Gene
VP2
Protein
Dual specificity protein phosphatase VP2
Organism
Chicken anemia virus (isolate USA CIA-1)
Length
216 amino acids
Function
May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication (By similarity).
Similarity
Belongs to the gyrovirus protein VP2 family.
Mass
24.139 kDa
Sequence
MHGNGGQPAAGGSESALSREGQPGPSGAAQGQVISNERSPRRYSTRTINGVQATNKFTAVGNPSLQRDPDWYRWNYNHSIAVWLRECSRSHAKICNCGQFRKHWFQECAGLEDRSTQASLEEAILRPLRVQGKRAKRKLDYHYSQPTPNRKKVYKTVRWQDELADREADFTPSEEDGGTTSSDFDEDINFDIGGDSGIVDELLGRPFTTPAPVRIV

Gene
VP2
Protein
Capsid protein VP2
Organism
Sulfolobus spindle-shape virus 1
Length
74 amino acids
Function
This extremely basic protein may tightly bind to SSV1 DNA. Essential for virus function.
Mass
8.827 kDa
Sequence
MKWVQKAIKRPGRVHRYLMRLYGKRAFTKDGDIKASYLDKAIKHVKKAKIPKEKKRSLLSALLLAKRLKRMHRK

Gene
VP2
Protein
Venom peptide 2-long
Organism
Orancistrocerus drewseni
Length
71 amino acids
Function
Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations. Also exhibits strong antimicrobial activity against the fungi B.cinerea (MIC=0.5 ug/ml) and C.albicans, and moderate activity against the Gram-positive bacterium S.aureus (MIC=25 ug/ml) and the Gram-negative bacterium E.coli. Venom peptide 2-long has substantially lower antimicrobial activity against C.albicans (MIC=100 ug/ml) and bacteria than Orancis-protonectin but has equivalent activity against B.cinerea (MIC=0.5 ug/ml).
Similarity
Belongs to the MCD family. Protonectin subfamily.
Mass
7.172 kDa
Sequence
MKQSIIIALFATIAVMACLQMVAAVPAPVPEAAPGPVAEAEAYASPEALASPEAEPILGIITSLLKSLGKK