About Products Protein Database Contact

VIP3

Gene
VIP3
Protein
WD repeat-containing protein VIP3
Organism
Arabidopsis thaliana
Length
321 amino acids
Function
Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3) (PubMed:20363855). Involved in regulation of flowering time. Required for the expression of the flowering repressor and MADS box gene FLC (PubMed:12750345, PubMed:18725930). Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) and histone dimethylation on 'Lys-36' (H3K36me2) at the FLC locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus (PubMed:18725930). Not required for meiotic recombination or progression (PubMed:16716192). Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:22511887). Required for proper progression of cell differentiation process (PubMed:23134555).
Mass
34.26 kDa
Sequence
MKLAGLKSIENAHEDSVWAATWVPATEDRPALLLTGSLDETVKLWRPDELDLVRTNTGHSLGVAALAAHPSGIIAASSSIDSFVRVFDVDTNATIAVLEAPPSEVWGMQFEPKGTILAVAGGSSASVKLWDTASWRLISTLSIPRPDAPKPSDKTSSKKFVLSVAWSPNGKRLACGSMDGTICVFDVDRSKLLHQLEGHNMPVRSLVFSPVDPRVLFSGSDDGHVNMHDAEGKTLLGSMSGHTSWVLSVDASPDGGAIATGSSDRTVRLWDLKMRAAIQTMSNHNDQVWSVAFRPPGGTGVRAGRLASVSDDKSVSLYDYS

Gene
VIP3
Protein
Probable prefoldin subunit 4
Organism
Avena fatua
Length
126 amino acids
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
Similarity
Belongs to the prefoldin subunit beta family.
Mass
14.669 kDa
Sequence
MQQGDGTEAQVTWEDQQNINRFGRLNNRFHELTDEIRLAKEANENLEDAGNELILCDEDVVRFQIGEVFAHMPMDDVEARLEQMKEDAAKKLERLEEEKESILAQMAELKKILYGKFKDAINLEED