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VC_A0210

Gene
VC_A0210
Protein
3'3'-cGAMP-specific phosphodiesterase 2
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Length
522 amino acids
Function
Phosphodiesterase (PDE) that catalyzes the hydrolysis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP), leading to linear 5'-pApG (PubMed:25837739, PubMed:30365951). Counteracts the function of the 3'3'-cGAMP synthase DncV, and is involved in the modulation of intracellular 3'3'-cGAMP levels. Enhances bacterial chemotaxis and inhibits intestinal colonization in vivo. Thus exerts a crucial role in regulating bacterial infectivity through catalyzing 3'3'-cGAMP degradation. Is specific for 3'3'-cGAMP since it cannot degrade other cGAMP linkage isomers (3'2'-, 2'3'-, and 2'2'-cGAMPs) (PubMed:25837739). Is also able to hydrolyze c-di-GMP but not c-di-AMP (PubMed:25343965, PubMed:25837739).
Mass
59.713 kDa
Sequence
MKWFKYGDGMDLFADMRQEAAGEKERVVMHSQEPWCVLLVDDDEQMHQITRLALTGFKFQNRPLELISVLSGLEARKVMAERSDIALALVDVVMETEHAGLDLVRYIREELQNRQVRLVLRTGQAGQAPEDRVIKEYEIDDYKEKTELTTQKLRTLLYSMLRAYRDLCLIEDQKLGLSHVIEASANVQNTKSLQSYATAVLNQLTSLLKLHASAFYCVATPCPDSEKCNALTVATTAERVELYVESPFKGLPEDVQRRCKEVLSQRTTRDYGDAYVFFKQDERGVDSVLYVGFEQELSELDRKLLEIYMYNIGLTFENINLMVDLRETSKELVYNLANAVEARSRETGAHVQRVALYCERLAHLYGLAESEADMIKNASPLHDVGKVAIPDSILHKPGKLDAQEWAIMQKHVEYGVEILNRSKRRLMQVAKEIAATHHEKWDGSGYPNRLQGDDIPISGRITAIADVFDALGAKRSYKDPWTDEQIREELMAQKGRHFEPKLVELLLEHWDEFIAIRASLPD