Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as lamellipodial and filopodial dynamics in migrating cells. Plays a crucial role in filopodia formation, cell-substratum adhesion, and proper chemotaxis. Nucleates and bundles actin filaments. When complexed with fotH in filopodial tips, may support formin-mediated filament elongation by bundling nascent actin filaments.
Sequence
MSETAIFNATGQVFTYSPQTRNWVPSSNVPATLQMYFNSGANTYRVIGRAGDDPNNFLINFAVKSEVVYSRASEIFHQFTDQRTHFGINFTSKQDADTFGGGFENVLRSLKGGPQQPPPQVPKPQPQQPPQPQQPPQRPPSTVIAKPVAPQAPVAPPQAPAAAPQAPAPPAAPPAPPKPPGPPPPPPAPKPPAAGGGTGRNALLGSIENFSKGGLKKTVTVDKSAGVPTKTTPSANSAASNAGSEPSSGGSTPAPAPKSSGGGGGGDLMAEVMAKRAKMKAAASQPKEESSAPTPAPTPAPTPAPTPSSTSFKPPQSFSKPATKTAAANKPPSPSLSAPLPSTVANEDLQSLKEEILTEVRKEIQKAKDEILEAIRASQH