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VASP

Gene
VASP
Protein
Vasodilator-stimulated phosphoprotein
Organism
Canis lupus familiaris
Length
384 amino acids
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity).
Similarity
Belongs to the Ena/VASP family.
Mass
40.413 kDa
Sequence
MSETVICSSWATVMLYDDSNKRWLPAGTGPQSFSRVQIYHNPTANSFRVVGWKMQPDQQVVINCAIVRGIKYNQATPTFHQWRDARQVWGLNFGSKEDATQFAAAMASALEALEGGGPPPPPPPAAPPTWSVQNGPASEEVEQQKRQQPGPPEHLERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGVSLSGGSAAGHGAGGGPPPAPPLPTAQGTSGGGTGAPGLAAAIAGAKLRKVSKQEEASGGPPVPKAESTRSTGGGLMEEMNAMLARRRKATQVGEKPPKDESANEEPEARVPVPAQSETVRRPWEKNSTTLPRMKSSSSVTTSEAHPSTPSSSDESDLERVKQELLEEVRKELQKVKEEIIEAFVQELRKRGSP

Gene
VASP
Protein
Vasodilator-stimulated phosphoprotein
Organism
Bos taurus
Length
383 amino acids
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity).
Similarity
Belongs to the Ena/VASP family.
Mass
40.463 kDa
Sequence
MSETVVCTSRATVMLYDDSNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDATQFANGMASALEALEGGGPLPPPPPTAPPTWSAQNGPSPEEMEQQKRQQQSELMERERRASNAGGPPAASAGAPPPPPGPPPPPGPPPPPGLSSSGVSAATQGAGGGPPPAPPLPTAQGPSGGGTGAPSLASAIAGAKLRKVSKQEEASAGPVAPKAESSRSTGGGLMEEMNAMLARRRKATQVGEKPAKDESANQEESDARVPAHSESVRRPWEKNSTTLPRMKSSSSVTTSEAHPATPSSSDESDLERVKQELLEEVRKELQKVKEEIIEAFVQELRKRGAP

Gene
vasp
Protein
Protein VASP homolog
Organism
Dictyostelium discoideum
Length
380 amino acids
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as lamellipodial and filopodial dynamics in migrating cells. Plays a crucial role in filopodia formation, cell-substratum adhesion, and proper chemotaxis. Nucleates and bundles actin filaments. When complexed with fotH in filopodial tips, may support formin-mediated filament elongation by bundling nascent actin filaments.
Similarity
Belongs to the Ena/VASP family.
Mass
39.107 kDa
Sequence
MSETAIFNATGQVFTYSPQTRNWVPSSNVPATLQMYFNSGANTYRVIGRAGDDPNNFLINFAVKSEVVYSRASEIFHQFTDQRTHFGINFTSKQDADTFGGGFENVLRSLKGGPQQPPPQVPKPQPQQPPQPQQPPQRPPSTVIAKPVAPQAPVAPPQAPAAAPQAPAPPAAPPAPPKPPGPPPPPPAPKPPAAGGGTGRNALLGSIENFSKGGLKKTVTVDKSAGVPTKTTPSANSAASNAGSEPSSGGSTPAPAPKSSGGGGGGDLMAEVMAKRAKMKAAASQPKEESSAPTPAPTPAPTPAPTPSSTSFKPPQSFSKPATKTAAANKPPSPSLSAPLPSTVANEDLQSLKEEILTEVRKEIQKAKDEILEAIRASQH

Gene
VASP
Protein
Vasodilator-stimulated phosphoprotein
Organism
Homo sapiens
Length
380 amino acids
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.
Similarity
Belongs to the Ena/VASP family.
Mass
39.83 kDa
Sequence
MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEGGGPPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGGAGAPGLAAAIAGAKLRKVSKQEEASGGPTAPKAESGRSGGGGLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVPAQSESVRRPWEKNSTTLPRMKSSSSVTTSETQPCTPSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSP

Gene
Vasp
Protein
Vasodilator-stimulated phosphoprotein
Organism
Mus musculus
Length
375 amino acids
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity).
Similarity
Belongs to the Ena/VASP family.
Mass
39.667 kDa
Sequence
MSETVICSSRATVMLYDDSNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAIQFATGMANALEALEGGGPPPAPAPPAWSAQNGPSPEELEQQKRQPEHMERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPSSGVSGAGHGAGAAPPPAPPLPTAQGPNSGGSGAPGLAAAIAGAKLRKVSKQEEASGGPLAPKAENSRSTGGGLMEEMNAMLARRRKATQVGEKPPKDESASEESEARLPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSTPCSSDDSDLERVKQELLEEVRKELQKMKEEIIEVFVQELRKRGSP