Ufd4

E3 ubiquitin-protein ligase Ufd4

2727 amino acids

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662).

Belongs to the UPL family. K-HECT subfamily.

302.15 kDa

MGDVDPETLLEWLSMGQGDERDMQLIALEQLCMLLLMSDNVDRCFESCPPRTFLPALCKIFLDELAPENVLEVTARAITYYLDVSAECTRRIVSIDGAIKAICNHLVVADLSSRTSRDLAEQCIKVLELICTREAGAVFEGGGLNCVLSFIRDCGSQVHKDTLHSAMSVVSRLCTKVEPNTPCIQNCVESLSTLLQHEDPMVSDGALKCFASVADRFTRKWVDPAPLAEYGLTTELLKRLQSVGGNTHSSLTAAGTQPTSSSQPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILRSQLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNTNTDRTHRQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADVNKGQRSSSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEWMSPDHSLLNKDGKKYTLMEPRGDPEMAPIYLKVLLPIFCRTFLGSMLGSVRRASLALIKKIVQYAYPTVLQSLSETSFSEDAASTSGQNGGNLLIEVIASVLDNEDDGDGHLIVLNIIEEIMCKTQEEFLDHFARLGVFAKVQALMDTDAEELYVQLPGTVEEPAAAQRSSTSVVVAPRPTSDDPMEDAKEILQGKPYHWREWSICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENGNDSSENRGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDDLPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFKSAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSSGLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTASILIQKLVSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTCDWVNPAQYGLVQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKEKGFHLN

UFD4

Ubiquitin fusion degradation protein 4

1483 amino acids

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Belongs to the UPL family. K-HECT subfamily.

167.843 kDa

MSENNSHNLDEHESHSENSDYMMDTQVEDDYDEDGHVQGEYSYYPDEDEDEHMLSSVGSFEADDGEDDDNDYHHEDDSGLLYGYHRTQNGSDEDRNEEEDGLERSHDNNEFGSNPLHLPDILETFAQRLEQRRQTSEGLGQHPVGRTLPEILSMIGGRMERSAESSARNERISKLIENTGNASEDPYIAMESLKELSENILMMNQMVVDRIIPMETLIGNIAAILSDKILREELELQMQACRCMYNLFEVCPESISIAVDEHVIPILQGKLVEISYIDLAEQVLETVEYISRVHGRDILKTGQLSIYVQFFDFLTIHAQRKAIAIVSNACSSIRTDDFKTIVEVLPTLKPIFSNATDQPILTRLVNAMYGICGALHGVDKFETLFSLDLIERIVQLVSIQDTPLENKLKCLDILTVLAMSSDVLSRELREKTDIVDMATRSFQHYSKSPNAGLHETLIYVPNSLLISISRFIVVLFPPEDERILSADKYTGNSDRGVISNQEKFDSLVQCLIPILVEIYTNAADFDVRRYVLIALLRVVSCINNSTAKAINDQLIKLIGSILAQKETASNANGTYSSEAGTLLVGGLSLLDLICKKFSELFFPSIKREGIFDLVKDLSVDFNNIDLKEDGNENISLSDEEGDLHSSIEECDEGDEEYDYEFTDMEIPDSVKPKKISIHIFRTLSLAYIKNKGVNLVNRVLSQMNVEQEAITEELHQIEGVVSILENPSTPDKTEEDWKGIWSVLKKCIFHEDFDVSGFEFTSTGLASSITKRITSSTVSHFILAKSFLEVFEDCIDRFLEILQSALTRLENFSIVDCGLHDGGGVSSLAKEIKIKLVYDGDASKDNIGTDLSSTIVSVHCIASFTSLNEFLRHRMVRMRFLNSLIPNLTSSSTEADREEEENCLDHMRKKNFDFFYDNEKVDMESTVFGVIFNTFVRRNRDLKTLWDDTHTIKFCKSLEGNNRESEAAEEANEGKKLRDFYKKREFAQVDTGSSADILTLLDFLHSCGVKSDSFINSKLSAKLARQLDEPLVVASGALPDWSLFLTRRFPFLFPFDTRMLFLQCTSFGYGRLIQLWKNKSKGSKDLRNDEALQQLGRITRRKLRISRKTIFATGLKILSKYGSSPDVLEIEYQEEAGTGLGPTLEFYSVVSKYFARKSLNMWRCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFGRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAGAFLLS