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US6

Gene
US6
Protein
Envelope glycoprotein D
Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997)
Length
383 amino acids
Function
Envelope glycoprotein that binds to host cell entry receptors. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
Similarity
Belongs to the herpesviridae glycoprotein D family.
Mass
42.036 kDa
Sequence
MPAATMATPGYLACRTSVATLLFFVLLRRAAILGAGGAPSPARIVDYLIGYTRVGDMDKLYSQYADRYLDVTLHGCERAVVDPLGDMRHVLASEGASGQEFTASVIWYYVFPDVCFAPVFRREYLRCIRPRKLEDCYTTSPFMWTREFYVDAFLAGSGTGIELLGLNKKLTGTYMLVVRVGTTTRTALVTVNVVGECPTTMEEVTTTLRGNCWRGRQYTTDFNGDGMYLFDTEEEHRRIVYKAYQDKLKVASPNATDAPISYPRAYTGADERLAPYTLQPVSTDDHYLPGCPWGIGCDLDQTSASGVIEIEDHDESDVRLVSYPPPTLPSPGPGGNENGAGYSDNRPDPKVVGPTVGPGAIILVVMCAPILIGLTAFTIRKYC

Gene
US6
Protein
Unique short US6 glycoprotein
Organism
Human cytomegalovirus (strain Towne)
Length
183 amino acids
Function
Inhibits peptide loading of MHC class I molecules by transporters associated with antigen processing (TAP). Does not prevent peptide binding to TAP, but binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1, but not TAP2. Also prevents the conformational rearrangement of TAP induced by peptide binding. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes (By similarity).
Similarity
Belongs to the cytomegalovirus US6 family.
Mass
20.639 kDa
Sequence
MDLLIRLGFLLMCALPTPGERSSRDPKTLLSLSPRQQACVPRTKSHRPVCYNDTGDCTDADDSWKQLGEDFAHQCLQAAKKRPKTHKSRPNDRNLEGRLTCQRVRRLLPCDLDIHPSHRLLTLMNNCVCDGAVWNAFRLIERHGFFAVTLYLCCGITLLVVILALLCSITYESTGRGIRRCGS

Gene
US6
Protein
Unique short US6 glycoprotein
Organism
Human cytomegalovirus (strain AD169)
Length
183 amino acids
Function
Inhibits peptide loading of MHC class I molecules by transporters associated with antigen processing (TAP). Does not prevent peptide binding to TAP, but binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1, but not TAP2. Also prevents the conformational rearrangement of TAP induced by peptide binding. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Similarity
Belongs to the cytomegalovirus US6 family.
Mass
20.639 kDa
Sequence
MDLLIRLGFLLMCALPTPGERSSRDPKTLLSLSPRQQACVPRTKSHRPVCYNDTGDCTDADDSWKQLGEDFAHQCLQAAKKRPKTHKSRPNDRNLEGRLTCQRVRRLLPCDLDIHPSHRLLTLMNNCVCDGAVWNAFRLIERHGFFAVTLYLCCGITLLVVILALLCSITYESTGRGIRRCGS

Gene
US6
Protein
Unique short US6 glycoprotein
Organism
Human cytomegalovirus (strain Merlin)
Length
182 amino acids
Function
Inhibits peptide loading of MHC class I molecules by transporters associated with antigen processing (TAP). Does not prevent peptide binding to TAP, but binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1, but not TAP2. Also prevents the conformational rearrangement of TAP induced by peptide binding. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes (By similarity).
Similarity
Belongs to the cytomegalovirus US6 family.
Mass
20.511 kDa
Sequence
MDLLIRLGFLLMCALPTPGERSSRDPKTLLSLSPRQACVPRTKSHRPVCYNDTGDCTDADDSWKQLGEDFAHQCLQAAKKRPKTHKSRPNDRNLEGRLTCQRVRRLLPCDLDIHPSHRLLTLMNNCVCDGAVWNAFRLIERHGFFAVTLYLCCGITLLVVILALLCSITYESTGRGIRRCGS