About Products Protein Database Contact

US2

Gene
US2
Protein
Serine/threonine-protein kinase
Organism
Equine herpesvirus 1 (strain Kentucky A)
Length
382 amino acids
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
42.503 kDa
Sequence
MENKQCDHLTDWFSTTSDASESMDTTPPLPPPTPSVDPSYSGAAADEDLYSDISEGDLEYSDCDSASESDEDDDDCLIPSKEKAREVAASFGYTVIKTLTPGSEGRVMVATKDGQPEPVVLKIGQKGTTLIEAMMLRNVNHPSVIQMKDTLVSGAITCMVLPHYSSDLYTFLTKESRRIPIDQALIIEKQILEGLRYLHAQRIIHRDVKTENIFINSVDQVCIADFGAAQFPVVEPADLGLAGTVETNAPEVLARAKYNSKADIWSAGIVLFEMLAYPSTLFEDPPSTPEEYVKSCHSQLLKIISTLKINPEEFPRDPGSRLVRGYIEYSRLERNAYTRYPCFQRVNLHIDGEFLVHKMLAFNAAMRPSAEELLSYPMFAQL

Gene
US2
Protein
Serine/threonine-protein kinase US3 homolog
Organism
Cercopithecine herpesvirus 9 (strain DHV)
Length
345 amino acids
Function
Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of apoptosis. Phosphorylates UL31 and UL34 homologs, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress. Modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3. Phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface. Promotes virus intracellular spread by restructuring host cell cytoskeleton. Blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing (By similarity).
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
38.954 kDa
Sequence
MNYDDDCLYEDKHMDTDIYDMLADEDTSDVDNTLAVCATARAGIEKAGFSVLETFTPGAEGFTFACIENKTRENVVIKAGQRGGTVTEAHILRNINHPVIIRLMGTFTYNSFTCLVLPRYKTDLYCYLSDRRRIAICDMLSIERSVLRAIQYLHENRIIHRDVKAENIFINHPGDVCLGDFGAACYPVDITQNKYYGWAGTIATNAPELLARDPYGPAVDIWSAGIVLFEMATCHDSLFEKDGLDGDCDSDRQIKLIIRRTGVHPSEFPIDAQATLDEIYRTCQKTSRKPGTRPTWTNLYELPLELEYLICKMLAFDAHKRPSAKALLDFAAFYDIPDPYPNPTN

Gene
US2
Protein
Protein US2
Organism
Human herpesvirus 1 (strain 17)
Length
291 amino acids
Similarity
Belongs to the herpesviridae HHV-1 US2 protein family.
Mass
32.471 kDa
Sequence
MGVVVVNVMTLLDQNNALPRTSVDASPALWSFLLRQCRILASEPLGTPVVVRPANLRRLAEPLMDLPKPTRPIVRTRSCRCPPNTTTGLFAEDSPLESTEVVDAVACFRLLHRDQPSPPRLYHLWVVGAADLCVPFLEYAQKIRLGVRFIAIKTPDAWVGEPWAVPTRFLPEWTVAWTPFPAAPNHPLETLLSRYEYQYGVVLPGTNGRERDCMRWLRSLIALHKPHPATPGPLTTSHPVRRPCCACMGMPEVPDEQPTSPGRGPQETDPLIAVRGERPRLPHICYPVTTL

Gene
US2
Protein
Protein US2
Organism
Human herpesvirus 2 (strain HG52)
Length
291 amino acids
Function
Plays a role in the activation of the host NF-kappa-B pathway by interacting with and thus activating the component MAP3K7.
Similarity
Belongs to the herpesviridae HHV-1 US2 protein family.
Mass
32.781 kDa
Sequence
MGVVVVSVVTLLDQRNALPRTSADASPALWSFLLRQCRILASEPLGTPVVVRPANLRRLAEPLMDLPKFTRPIVRTRSCRCPPNTTTGLFAEDDPLESIEILDAPACFRLLHQERPGPHRLYHLWVVGAADLCVPFFEYAQKTRLGFRFIATKTNDAWVGEPWPLPDRFLPERTVSWTPFPAAPNHPLENLLSRYEYQYGVVVPGDRERSCLRWLRSLVAPHNKPRPASSRPHPATHPTQRPCFTCMGRPEIPDEPSWQTGDDDPQNPGPPLAVGDEWPPSSHVCYPITNL

Gene
US2
Protein
Unique short US2 glycoprotein
Organism
Human cytomegalovirus (strain AD169)
Length
199 amino acids
Function
Early protein that redirects newly synthesized MHC class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes. Seems so far to be specific for HLA-A, HLA-B, and HFE loci products. Does not interact with HLA-DR or HLA-DM.
Similarity
Belongs to the cytomegalovirus US2 family.
Mass
23.111 kDa
Sequence
MNNLWKAWVGLWTSMGPLIRLPDGITKAGEDALRPWKSTAKHPWFQIEDNRCYIDNGKLFARGSIVGNMSRFVFDPKADYGGVGENLYVHADDVEFVPGESLKWNVRNLDVMPIFETLALRLVLQGDVIWLRCVPELRVDYTSSAYMWNMQYGMVRKSYTHVAWTIVFYSINITLLVLFIVYVTVDCNLSMMWMRFFVC

Gene
US2
Protein
Unique short US2 glycoprotein
Organism
Human cytomegalovirus (strain Merlin)
Length
199 amino acids
Function
Early protein that redirects newly synthesized MHC class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes. Seems so far to be specific for HLA-A, HLA-B, and HFE loci products. Does not interact with HLA-DR or HLA-DM (By similarity).
Similarity
Belongs to the cytomegalovirus US2 family.
Mass
23.112 kDa
Sequence
MNNLWKAWVGLWTSMGPLIRLPDGITKAGEDALRPWKSTAKHPWFEIEDNRCYIDNGKLFARGSIVGNMSRFVFDPKADYGGVGENLYVHADDVEFVPGESLKWNVRNLDVMPIFETLALRLVLQGDVIWLRCVPELRVDYTSSAYMWNMQYGMVRKSYTHVAWTIVFYSINITLLVLFIVYVTVDCNLSMMWMRFFVC

Gene
US2
Protein
Unique short US2 glycoprotein
Organism
Human cytomegalovirus (strain Towne)
Length
199 amino acids
Function
Early protein that redirects newly synthesized MHC class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes. Seems so far to be specific for HLA-A, HLA-B, and HFE loci products. Does not interact with HLA-DR or HLA-DM (By similarity).
Similarity
Belongs to the cytomegalovirus US2 family.
Mass
23.111 kDa
Sequence
MNNLWKAWVGLWTSMGPLIRLPDGITKAGEDALRPWKSTAKHPWFQIEDNRCYIDNGKLFARGSIVGNMSRFVFDPKADYGGVGENLYVHADDVEFVPGESLKWNVRNLDVMPIFETLALRLVLQGDVIWLRCVPELRVDYTSSAYMWNMQYGMVRKSYTHVAWTIVFYSINITLLVLFIVYVTVDCNLSMMWMRFFVC

Gene
US2
Protein
Uncharacterized protein US2
Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997)
Length
86 amino acids
Mass
9.139 kDa
Sequence
MSPARINVAACIDSSGSLPIELPVLSDAAGRELLNASPKMTESDDPVALPIIMRPTEPSCVCSVVLLLPRMRGPVIRISMGVPDWL